W A van Schalkwyk1, J Opie, N Novitzky. 1. Department of Haematology, Groote Schuur Hospital and National Health Laboratory Service, University of Cape Town, Cape Town, South Africa. willem.vanschalkwyk@nhls.ac.za
Abstract
INTRODUCTION: A bone marrow biopsy is frequently requested in the work-up of patients with human immunodeficiency virus (HIV) infection who present with fever and/or cytopenias in the search for opportunistic infections and malignancies. METHODS: This is a retrospective review of the results of consecutive bone marrow biopsies performed at our institution over a three-year period on HIV-positive patients for the investigation of fever and/or cytopenias. Clinical data, haematological parameters, morphological features, Ziehl-Neelsen staining and microbiological culture results were analysed. The aim of the study was to determine the diagnostic yield of this investigation. RESULTS: Sixty-three males and 84 female patients were included for analysis. The bone marrow biopsy gave a high diagnostic yield of 47% (70 patients) and a unique diagnosis in 33% (49 patients). Immune thrombocytopenic purpura and disseminated mycobacterial infections were the most common unique diagnoses made (14%, respectively), followed by malignancies (4%). In this cohort, four cases of primary bone marrow involvement by Hodgkin lymphoma and one case of involvement by non-Hodgkin lymphoma were diagnosed. CONCLUSION: In our study group, a bone marrow biopsy was a useful investigation with a high diagnostic yield.
INTRODUCTION: A bone marrow biopsy is frequently requested in the work-up of patients with human immunodeficiency virus (HIV) infection who present with fever and/or cytopenias in the search for opportunistic infections and malignancies. METHODS: This is a retrospective review of the results of consecutive bone marrow biopsies performed at our institution over a three-year period on HIV-positive patients for the investigation of fever and/or cytopenias. Clinical data, haematological parameters, morphological features, Ziehl-Neelsen staining and microbiological culture results were analysed. The aim of the study was to determine the diagnostic yield of this investigation. RESULTS: Sixty-three males and 84 female patients were included for analysis. The bone marrow biopsy gave a high diagnostic yield of 47% (70 patients) and a unique diagnosis in 33% (49 patients). Immune thrombocytopenic purpura and disseminated mycobacterial infections were the most common unique diagnoses made (14%, respectively), followed by malignancies (4%). In this cohort, four cases of primary bone marrow involvement by Hodgkin lymphoma and one case of involvement by non-Hodgkin lymphoma were diagnosed. CONCLUSION: In our study group, a bone marrow biopsy was a useful investigation with a high diagnostic yield.
Authors: Karin van den Berg; James van Hasselt; Evan Bloch; Robert Crookes; James Kelley; Jonathan Berger; Charlotte Ingram; Anel Dippenaar; Rajendra Thejpal; Neil Littleton; Tersia Elliz; Gary Reubenson; Mark Cotton; Jennifer C Hull; Pamela Moodley; Yasmin Goga; William Eldridge; Moosa Patel; Eric Hefer; Arthur Bird Journal: South Afr J HIV Med Date: 2012-06-07 Impact factor: 2.744
Authors: Margareth Castro Ozelo; Marina Pereira Colella; Erich Vinícius de Paula; Ana Clara Kneese Virgilio do Nascimento; Paula Ribeiro Villaça; Wanderley Marques Bernardo Journal: Hematol Transfus Cell Ther Date: 2018-02-17