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Literature DB >> 2111700

The oxidation of leucine in tumour-bearing rats.

Abstract

Rats bearing the Walker-256 carcinosarcoma showed significant changes in leucine metabolism compared with their non-tumour-bearing controls. After a single intravenous tracer dose of L-[1-14C]leucine in vivo, 14CO2 release by tumour-bearing rats was significantly elevated throughout the time course of administration. In addition, both the clearance and turnover rates of the tracer were significantly enhanced in these animals. Incubation of soleus muscles from control and tumour-bearing rats in the presence of L-[1-14C]leucine revealed an enhanced oxidation of the amino acid in the tumour-bearing group. Tumour tissue slices were also able to oxidize the tracer at a similar rate to that found in soleus muscles from control animals.

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Year: 1990 PMID： 2111700 PMCID： PMC1131419 DOI： 10.1042/bj2680241

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

21 in total

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Journal: Cancer Res Date: 1969-06 Impact factor: 12.701

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Journal: Mol Cell Biochem Date: 1988-05 Impact factor: 3.396

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Authors: P A Lazo
Journal: FEBS Lett Date: 1985-08-05 Impact factor: 4.124

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Authors: K Lundholm; L Ekman; S Edström; I Karlberg; R Jagenburg; T Scherstén
Journal: Cancer Res Date: 1979-11 Impact factor: 12.701

10. Ketone-body metabolism in tumour-bearing rats.

Authors: A M Rofe; R Bais; R A Conyers
Journal: Biochem J Date: 1986-01-15 Impact factor: 3.857

5 in total

1. Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues.

Authors: Bagganahalli S Somashekar; Pachiyappan Kamarajan; Theodora Danciu; Yvonne L Kapila; Arul M Chinnaiyan; Thekkelnaycke M Rajendiran; Ayyalusamy Ramamoorthy
Journal: J Proteome Res Date: 2011-10-18 Impact factor: 4.466

2. Lipopolysaccharide (LPS) increases the in vivo oxidation of branched-chain amino acids in the rat: a cytokine-mediated effect.

Authors: C García-Martínez; M Llovera; F J López-Soriano; B del Santo; J M Argilés
Journal: Mol Cell Biochem Date: 1995-07-05 Impact factor: 3.396