| Literature DB >> 21116958 |
Jeffrey D Clogston1, Anil K Patri.
Abstract
This chapter describes a method for the measurement of free gadolinium in nanoparticle samples. Conjugation of a gadolinium-chelate to a nanoparticle allows the particle's distribution to be imaged via magnetic resonance imaging (MRI). Free (unchelated) gadolinium is a known toxin, being a heavy metal, and may contribute towards total gadolinium concentration. Determining the amount of free gadolinium is therefore an important aspect of the preclinical characterization of gadolinium-chelate MRI imaging agent nanoparticles.Entities:
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Year: 2011 PMID： 21116958 DOI： 10.1007/978-1-60327-198-1_10
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745