Literature DB >> 21116102

The potential cardioprotective effects of hydrogen in irradiated mice.

Liren Qian1, Fei Cao, Jianguo Cui, Yicun Wang, Yuecheng Huang, Yunhai Chuai, Luqian Zaho, Hao Jiang, Jianming Cai.   

Abstract

Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ionizing irradiation injury in mice. In this paper, we demonstrate that hydrogen can protect myocardium degeneration from radiation-induced injury, decrease myocardium malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG) levels, and increase myocardium endogenous antioxidants in vivo. We suggest that hydrogen has a cardioprotective effect against radiation induced injury.

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Year:  2010        PMID： 21116102     DOI： 10.1269/jrr.10093

Source DB:  PubMed          Journal:  J Radiat Res        ISSN： 0449-3060            Impact factor:   2.724


  35 in total

1.  Up-regulation of peroxisome proliferator-activated receptor gamma in radiation-induced heart injury in rats.

Authors:  Song Gao; Rong Wu; Yuecan Zeng
Journal:  Radiat Environ Biophys       Date:  2011-10-14       Impact factor: 1.925

Review 2.  Effects of ionizing radiation on the heart.

Authors:  Marjan Boerma; Vijayalakshmi Sridharan; Xiao-Wen Mao; Gregory A Nelson; Amrita K Cheema; Igor Koturbash; Sharda P Singh; Alan J Tackett; Martin Hauer-Jensen
Journal:  Mutat Res Rev Mutat Res       Date:  2016-07-10       Impact factor: 5.657

Review 3.  Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment.

Authors:  Johan Spetz; Javid Moslehi; Kristopher Sarosiek
Journal:  Curr Treat Options Cardiovasc Med       Date:  2018-03-20

Review 4.  Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent.

Authors:  Shin-Ichi Hirano; Yusuke Ichikawa; Bunpei Sato; Haru Yamamoto; Yoshiyasu Takefuji; Fumitake Satoh
Journal:  Int J Mol Sci       Date:  2021-04-27       Impact factor: 5.923

5.  A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution.

Authors:  Yunhai Chuai; Luqian Zhao; Jin Ni; Ding Sun; Jianguo Cui; Bailong Li; Liren Qian; Fu Gao; Jianming Cai
Journal:  Med Sci Monit       Date:  2011-04

6.  Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis.

Authors:  Yanyong Yang; Bailong Li; Cong Liu; Yunhai Chuai; Jixiao Lei; Fu Gao; Jianguo Cui; Ding Sun; Ying Cheng; Chuanfeng Zhou; Jianming Cai
Journal:  Med Sci Monit       Date:  2012-04

7.  Hydrogen therapy may be an effective and specific novel treatment for acute graft-versus-host disease (GVHD).

Authors:  Liren Qian; Jianliang Shen
Journal:  J Cell Mol Med       Date:  2013-06-07       Impact factor: 5.310

8.  Gamma-ray irradiation impairs dendritic cell migration to CCL19 by down-regulation of CCR7 and induction of cell apoptosis.

Authors:  Cong Liu; Jin Lin; Luqian Zhao; Yanyong Yang; Fu Gao; Bailong Li; Jianguo Cui; Jianming Cai
Journal:  Int J Biol Sci       Date:  2011-02-14       Impact factor: 6.580

9.  Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice.

Authors:  Luqian Zhao; Chuanfeng Zhou; Jian Zhang; Fu Gao; Bailong Li; Yunhai Chuai; Cong Liu; Jianming Cai
Journal:  Int J Biol Sci       Date:  2011-03-25       Impact factor: 6.580

10.  The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance.

Authors:  Brandon J Dixon; Jiping Tang; John H Zhang
Journal:  Med Gas Res       Date:  2013-05-16
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