BACKGROUND: Preoperative biomarkers serum CEA and plasma TIMP-1 have been shown to have prognostic and predictive value in patients with colorectal cancer. The aim of the present study was to evaluate the possible impact of chemoradiotherapy (CRT) on preoperative biomarker levels in patients with rectal cancer. PATIENTS AND METHODS: Thirty-three patients with rectal cancer were prospectively included. The patients received CRT for 6-8 weeks. Blood samples were collected before CRT (pre-CRT) and preoperatively (post-CRT). RESULTS: Median CEA was 3.5 (range 0.6-36.1) μg/l and 2.4 (range 0.0-10.2) μg/l (p=0.002) and median plasma TIMP-1 was 132.1 (range 77.8-342.7) μg/l and 140.0 (range 82.6-440.9) μg/l (p=0.04) in the pre- and post-CRT measurements, respectively. CONCLUSION: CRT induced a significant decrease in serum CEA and increase in plasma TIMP-1 levels. Therefore, the preoperative biomarker levels may be affected by treatments received before blood sample collection. Translation of results of preoperative biomarkers needs to take such facts into consideration.
BACKGROUND: Preoperative biomarkers serum CEA and plasma TIMP-1 have been shown to have prognostic and predictive value in patients with colorectal cancer. The aim of the present study was to evaluate the possible impact of chemoradiotherapy (CRT) on preoperative biomarker levels in patients with rectal cancer. PATIENTS AND METHODS: Thirty-three patients with rectal cancer were prospectively included. The patients received CRT for 6-8 weeks. Blood samples were collected before CRT (pre-CRT) and preoperatively (post-CRT). RESULTS: Median CEA was 3.5 (range 0.6-36.1) μg/l and 2.4 (range 0.0-10.2) μg/l (p=0.002) and median plasma TIMP-1 was 132.1 (range 77.8-342.7) μg/l and 140.0 (range 82.6-440.9) μg/l (p=0.04) in the pre- and post-CRT measurements, respectively. CONCLUSION:CRT induced a significant decrease in serum CEA and increase in plasma TIMP-1 levels. Therefore, the preoperative biomarker levels may be affected by treatments received before blood sample collection. Translation of results of preoperative biomarkers needs to take such facts into consideration.
Authors: Alexander Gaber; Christina Stene; Kristina Hotakainen; Björn Nodin; Ingrid Palmquist; Anders Bjartell; Ulf-Håkan Stenman; Bengt Jeppsson; Louis B Johnson; Karin Jirström Journal: Radiat Oncol Date: 2011-08-24 Impact factor: 3.481
Authors: Xiaoxiao Li; James LeBlanc; Allison Truong; Ravi Vuthoori; Sharon S Chen; Jonathan L Lustgarten; Bennett Roth; Jeff Allard; Andrew Ippoliti; Laura L Presley; James Borneman; William L Bigbee; Vanathi Gopalakrishnan; Thomas G Graeber; David Elashoff; Jonathan Braun; Lee Goodglick Journal: PLoS One Date: 2011-11-21 Impact factor: 3.240
Authors: Peter Jo; Azadeh Azizian; Junius Salendo; Frank Kramer; Markus Bernhardt; Hendrik A Wolff; Jens Gruber; Marian Grade; Tim Beißbarth; B Michael Ghadimi; Jochen Gaedcke Journal: Int J Mol Sci Date: 2017-05-27 Impact factor: 5.923