| Literature DB >> 21115793 |
David B Olsen1, Mary-Ellen Davies, Larry Handt, Kenneth Koeplinger, Nanyan Rena Zhang, Steven W Ludmerer, Donald Graham, Nigel Liverton, Malcolm MacCoss, Daria Hazuda, Steven S Carroll.
Abstract
Efforts to develop novel, interferon-sparing therapies for treatment of chronic hepatitis C (HCV) infection are contingent on the ability of combination therapies consisting of direct antiviral inhibitors to achieve a sustained virologic response. This work demonstrates a proof of concept that coadministration of the nucleoside analogue MK-0608 with the protease inhibitor MK-7009, both of which produced robust viral load declines as monotherapy, to an HCV-infected chimpanzee can achieve a cure of infection.Entities:
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Year: 2010 PMID： 21115793 PMCID： PMC3028818 DOI： 10.1128/AAC.00990-10
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191