B Vincenzi1, S Galluzzo2, D Santini1, L Rocci1, F Loupakis3, P Correale4, R Addeo5, A Zoccoli1, A Napolitano1, F Graziano6, A Ruzzo7, A Falcone4, G Francini5, G Dicuonzo8, G Tonini1. 1. Department of Medical Oncology, University Campus Bio-Medico, Rome. 2. Department of Medical Oncology, University Campus Bio-Medico, Rome. Electronic address: s.galluzzo@unicampus.it. 3. Unit of Medical Oncology, Azienda-Ospedaliero Universitaria Pisana, University of Pisa, Pisa. 4. Section of Medical Oncology, Department "Giorgio Segre" of Pharmacology, University of Siena, Siena. 5. Oncology Department, "S. Giovanni di Dio" Hospital, Frattaminore. 6. Unit of Medical Oncology, Hospital of Pesaro, Pesaro. 7. Section of Biochemistry and Molecular Biology "G. Fornaini", Department of Biomolecular Sciences, University of Urbino, Urbino. 8. Laboratory Medicine, University Campus Bio-Medico, Rome, Italy.
Abstract
BACKGROUND: KRAS wild-type mutational status is necessary but not sufficient to get benefit from epidermal growth factor receptor inhibition. Predictive markers are currently being evaluated. In this study, we investigated early hypomagnesemia as a predictor of efficacy and outcome in terms of time to progression (TtP) and overall survival (OS) in a cohort of patients affected by advanced colorectal adenocarcinoma KRAS wild-type cetuximab-treated. PATIENTS AND METHODS: One hundred and forty-three patients affected by stage IV colorectal adenocarcinoma KRAS wild type receiving cetuximab + irinotecan (CTX+IRI) as third-line anticancer treatment and resistant to oxaliplatin- and irinotecan-based chemotherapy were retrospectively included. Magnesium plasma levels were measured before the first day and 7, 14, 21 and 28 days after CTX+IRI infusion. RESULTS: The median magnesium basal value showed a statistically significant decrease after the start of CTX+IRI treatment (at 28 days, P < 0.0001). Patients with an early decrease of magnesium levels >50% compared with the basal level had a higher tumor response rate (55.8% versus 16.7%, P < 0.0001), a longer TtP (6.3 versus 3.6, P < 0.0001) and a longer median OS (11.0 versus 8.1, P = 0.002). CONCLUSIONS: We have shown that early hypomagnesemia could be a predictor of efficacy and outcome in those patients. Magnesium circulating level is an easy and inexpensive biomarker to routinely be detected in patients treated with cetuximab.
BACKGROUND:KRAS wild-type mutational status is necessary but not sufficient to get benefit from epidermal growth factor receptor inhibition. Predictive markers are currently being evaluated. In this study, we investigated early hypomagnesemia as a predictor of efficacy and outcome in terms of time to progression (TtP) and overall survival (OS) in a cohort of patients affected by advanced colorectal adenocarcinoma KRAS wild-type cetuximab-treated. PATIENTS AND METHODS: One hundred and forty-three patients affected by stage IV colorectal adenocarcinoma KRAS wild type receiving cetuximab + irinotecan (CTX+IRI) as third-line anticancer treatment and resistant to oxaliplatin- and irinotecan-based chemotherapy were retrospectively included. Magnesium plasma levels were measured before the first day and 7, 14, 21 and 28 days after CTX+IRI infusion. RESULTS: The median magnesium basal value showed a statistically significant decrease after the start of CTX+IRI treatment (at 28 days, P < 0.0001). Patients with an early decrease of magnesium levels >50% compared with the basal level had a higher tumor response rate (55.8% versus 16.7%, P < 0.0001), a longer TtP (6.3 versus 3.6, P < 0.0001) and a longer median OS (11.0 versus 8.1, P = 0.002). CONCLUSIONS: We have shown that early hypomagnesemia could be a predictor of efficacy and outcome in those patients. Magnesium circulating level is an easy and inexpensive biomarker to routinely be detected in patients treated with cetuximab.
Authors: T Kogawa; A Doi; M Shimokawa; T M Fouad; T Osuga; F Tamura; T Mizushima; T Kimura; S Abe; H Ihara; T Kukitsu; T Sumiyoshi; N Yoshizaki; M Hirayama; T Sasaki; Y Kawarada; S Kitashiro; S Okushiba; H Kondo; Y Tsuji Journal: Target Oncol Date: 2014-05-27 Impact factor: 4.493
Authors: I Pajares Bernad; J Martínez Trufero; L Calera Urquizu; R A Pazo Cid; A Cebollero de Miguel; M J Agustin; M Lanzuela; A Antón Journal: Clin Transl Oncol Date: 2017-01-24 Impact factor: 3.340