Literature DB >> 21113501

Cellular expression of INK4a gene in cells of bladder cancer associated with human papilloma virus-16.

G M Volgareva1, L E Zavalishina, D A Golovina, Yu Yu Andreeva, V D Ermilova, O B Trofimova, D A Kuevda, O Yu Shipulina, V A Glazunova, Shuling Cheng, L S Pavlova, N L Cheban, V B Matveev, G A Frank.   

Abstract

Hyperexpression of p16(INK4a) protein is an early marker of cervical cancer. Hyperexpression of INK4a gene encoding this protein at the level of mRNA and p16(INK4a) was detected in tumor cells of some patients with bladder cancer associated with human papilloma virus-16. However, in contrast to cervical cancer, this phenomenon in urothelial carcinomas does not correlate with expression of human papilloma virus-16 oncogenes E6 and E7.

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Year:  2010        PMID: 21113501     DOI: 10.1007/s10517-010-0917-0

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN: 0007-4888            Impact factor:   0.804


  1 in total

1.  Overexpression of p16(INK4a) in urothelial carcinoma in situ is a marker for MAPK-mediated epithelial-mesenchymal transition but is not related to human papillomavirus infection.

Authors:  Julie Steinestel; Marcus V Cronauer; Johannes Müller; Andreas Al Ghazal; Peter Skowronek; Annette Arndt; Klaus Kraft; Mark Schrader; Andres J Schrader; Konrad Steinestel
Journal:  PLoS One       Date:  2013-05-28       Impact factor: 3.240

  1 in total

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