Literature DB >> 21113488

Effect of bovine serum albumin on mitochondrial respiration in the brain and liver of mice and rats.

A V Panov1, V A Vavilin, V V Lyakhovich, B R Brooks, H L Bonkovsky.   

Abstract

We studied the effect of BSA (in the isolation medium) on the oxidation rate of succinate, glutamate, pyruvate, and α-ketoglutarate by mitochondria of the brain and liver from C57Bl/6g mice and Taconic Sprague Dawley rats. BSA had no effect on liver mitochondrial respiration, but increased oxidation of substrates (particularly of succinate) in brain mitochondria. Therefore, the major effect of BSA on brain mitochondria is manifested in activation of SDH. The improvement of mitochondrial properties in the brain after treatment with BSA is associated with antioxidant activity of this agent. Our results confirm the hypothesis that inhibition of SDH in brain mitochondria is not the artifact. This process serves as a mechanism protecting neurons from free oxygen radicals during succinate oxidation.

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Year:  2010        PMID： 21113488     DOI： 10.1007/s10517-010-0904-5

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  10 in total

1.  Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress.

Authors:  Rafal R Nazarewicz; Anna E Dikalova; Alfiya Bikineyeva; Sergey I Dikalov
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-08-16       Impact factor: 4.733

2.  Metabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology.

Authors:  Alexander V Panov; Nataliya Kubalik; Natalia Zinchenko; Daisy M Ridings; David A Radoff; Richelle Hemendinger; Benjamin R Brooks; Herbert L Bonkovsky
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2011-01-19       Impact factor: 3.619

Review 3.  Role of mitochondrial oxidative stress in hypertension.

Authors:  Sergey I Dikalov; Zoltan Ungvari
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-09-16       Impact factor: 4.733

4.  Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration.

Authors:  Brian D Fink; Fan Bai; Liping Yu; Ryan D Sheldon; Arpit Sharma; Eric B Taylor; William I Sivitz
Journal:  J Biol Chem       Date:  2018-11-01       Impact factor: 5.157

5.  Modulation of complex II-energized respiration in muscle, heart, and brown adipose mitochondria by oxaloacetate and complex I electron flow.

Authors:  Brian D Fink; Liping Yu; William I Sivitz
Journal:  FASEB J       Date:  2019-08-01       Impact factor: 5.191

6.  Bioenergetic and antiapoptotic properties of mitochondria from cultured human prostate cancer cell lines PC-3, DU145 and LNCaP.

Authors:  Alexander Panov; Zulfiya Orynbayeva
Journal:  PLoS One       Date:  2013-08-08       Impact factor: 3.240

7.  Voltage-Dependent Regulation of Complex II Energized Mitochondrial Oxygen Flux.

Authors:  Fan Bai; Brian D Fink; Liping Yu; William I Sivitz
Journal:  PLoS One       Date:  2016-05-06       Impact factor: 3.240

8.  Preparation of fatty acid solutions exerts significant impact on experimental outcomes in cell culture models of lipotoxicity.

Authors:  Axel Römer; Divya Rawat; Thomas Linn; Sebastian F Petry
Journal:  Biol Methods Protoc       Date:  2021-12-03

9.  Membrane potential-dependent regulation of mitochondrial complex II by oxaloacetate in interscapular brown adipose tissue.

Authors:  Brian D Fink; Adam J Rauckhorst; Eric B Taylor; Liping Yu; William I Sivitz
Journal:  FASEB Bioadv       Date:  2021-12-03

Review 10.  Fatty acids in energy metabolism of the central nervous system.

Authors:  Alexander Panov; Zulfiya Orynbayeva; Valentin Vavilin; Vyacheslav Lyakhovich
Journal:  Biomed Res Int       Date:  2014-05-04       Impact factor: 3.411
  10 in total

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