| Literature DB >> 21113457 |
N V Ryazantseva1, V V Novitskii, O B Zhukova, A K Biktasova, O E Chechina, E V Sazonova, T T Radzivil, A N Wice, N Yu Chasovskikh.
Abstract
The effect of recombinant TNF-α on programmed death of donor lymphocytes was studied in vitro. The proapoptotic effect of this cytokine is realized through transcription factors and cell cycle inhibitors. Incubation of lymphocytes with recombinant TNF-α revealed increased levels of NF-kB and p21 and reducted content of nonphosphorylated p53.Entities:
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Year: 2010 PMID： 21113457 DOI： 10.1007/s10517-010-0873-8
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804