Literature DB >> 21113258

The Bloodgen Project of the European Union, 2003-2009.

Neil D Avent1, Antonio Martinez, Willy A Flegel, Martin L Olsson, Marion L Scott, Núria Nogués, Martin Písăcka, Geoff L Daniels, Eduardo Muñiz-Diaz, Tracey E Madgett, Jill R Storry, Sigrid Beiboer, Petra M Maaskant-van Wijk, Inge von Zabern, Elisa Jiménez, Diego Tejedor, Monica López, Emma Camacho, Goedele Cheroutre, Anita Hacker, Pavel Jinoch, Irena Svobodova, Ellen van der Schoot, Masja de Haas.   

Abstract

The Bloodgen project was funded by the European Commission between 2003 and 2006, and involved academic blood centres, universities, and Progenika Biopharma S.A., a commercial supplier of genotyping platforms that incorporate glass arrays. The project has led to the development of a commercially available product, BLOODchip, that can be used to comprehensively genotype an individual for all clinically significant blood groups. The intention of making this system available is that blood services and perhaps even hospital blood banks would be able to obtain extended information concerning the blood group of routine blood donors and vulnerable patient groups. This may be of significant use in the current management of multi-transfused patients who become alloimmunised due to incomplete matching of blood groups. In the future it can be envisaged that better matching of donor-patient blood could be achieved by comprehensive genotyping of every blood donor, especially regular ones. This situation could even be extended to genotyping every individual at birth, which may prove to have significant long-term health economic benefits as it may be coupled with detection of inborn errors of metabolism.

Entities:  

Year:  2009        PMID: 21113258      PMCID: PMC2980524          DOI: 10.1159/000218192

Source DB:  PubMed          Journal:  Transfus Med Hemother        ISSN: 1660-3796            Impact factor:   3.747


  41 in total

1.  Weak D alleles express distinct phenotypes.

Authors:  F F Wagner; A Frohmajer; B Ladewig; N I Eicher; C B Lonicer; T H Müller; M H Siegel; W A Flegel
Journal:  Blood       Date:  2000-04-15       Impact factor: 22.113

2.  Kell typing by allele-specific PCR (ASP).

Authors:  N D Avent; P G Martin
Journal:  Br J Haematol       Date:  1996-06       Impact factor: 6.998

Review 3.  The use of maternal plasma for prenatal RhD blood group genotyping.

Authors:  Kirstin Finning; Pete Martin; Geoff Daniels
Journal:  Methods Mol Biol       Date:  2009

4.  Detection of fetal RHD-specific sequences in maternal plasma.

Authors:  B H Faas; E A Beuling; G C Christiaens; A E von dem Borne; C E van der Schoot
Journal:  Lancet       Date:  1998-10-10       Impact factor: 79.321

Review 5.  Molecular testing for transfusion medicine.

Authors:  Connie M Westhoff
Journal:  Curr Opin Hematol       Date:  2006-11       Impact factor: 3.284

6.  Rhesus D genotyping using polymerase chain reaction.

Authors:  L C Wolter; C A Hyland; A Saul
Journal:  Blood       Date:  1993-09-01       Impact factor: 22.113

7.  Prenatal determination of fetal RhD type.

Authors:  S Simsek; P M Bleeker; A E von dem Borne
Journal:  N Engl J Med       Date:  1994-03-17       Impact factor: 91.245

8.  Rearrangements of the blood group RhD gene associated with the DVI category phenotype.

Authors:  I Mouro; C Le Van Kim; C Rouillac; D J van Rhenen; P Y Le Pennec; P Bailly; J P Cartron; Y Colin
Journal:  Blood       Date:  1994-02-15       Impact factor: 22.113

9.  Large scale blood group genotyping.

Authors:  Neil D Avent
Journal:  Transfus Clin Biol       Date:  2007-05-23       Impact factor: 1.406

Review 10.  Prenatal typing of Rh and Kell blood group system antigens: the edge of a watershed.

Authors:  C Ellen van der Schoot; G H Martine Tax; Robbert J P Rijnders; Masja de Haas; Godelieve C M L Christiaens
Journal:  Transfus Med Rev       Date:  2003-01
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  20 in total

1.  Will Genotyping Replace Serology in Future Routine Blood Grouping? - Opinion 5.

Authors:  C Ellen van der Schoot; Barbera Veldhuisen; Masja de Haas
Journal:  Transfus Med Hemother       Date:  2009-05-28       Impact factor: 3.747

2.  Molecular Blood Group Diagnostics.

Authors:  Christoph Gassner
Journal:  Transfus Med Hemother       Date:  2009       Impact factor: 3.747

3.  Evaluation of red blood cell and platelet antigen genotyping platforms (ID CORE XT/ID HPA XT) in routine clinical practice.

Authors:  Kirstin Finning; Radhika Bhandari; Fiona Sellers; Nicoletta Revelli; Maria Antonietta Villa; Eduardo Muñiz-Díaz; Núria Nogués
Journal:  Blood Transfus       Date:  2015-10-29       Impact factor: 3.443

4.  Applying molecular immunohaematology to regularly transfused thalassaemic patients in Thailand.

Authors:  Pairaya Rujirojindakul; Willy A Flegel
Journal:  Blood Transfus       Date:  2013-10-03       Impact factor: 3.443

5.  The challenge and paradox in serology RhD typing for blood donors and patients.

Authors:  Catherine A Hyland
Journal:  Blood Transfus       Date:  2012-07-12       Impact factor: 3.443

6.  External quality assessment in molecular immunohematology: the INSTAND proficiency test program.

Authors:  Willy A Flegel; Ion Chiosea; Ulrich J Sachs; Gregor Bein
Journal:  Transfusion       Date:  2013-09-20       Impact factor: 3.157

7.  The AQP1 mutation c.601delG causes the Co-negative phenotype in four patients belonging to the Romani (Gypsy) ethnic group.

Authors:  Brigitte K Flesch; Burkhard Just; Robert Deitenbeck; Angelika Reil; Jürgen Bux; Núria Nogués; Eduardo Muñiz-Diaz
Journal:  Blood Transfus       Date:  2013-10-18       Impact factor: 3.443

8.  It's time to phase in RHD genotyping for patients with a serologic weak D phenotype. College of American Pathologists Transfusion Medicine Resource Committee Work Group.

Authors:  S Gerald Sandler; Willy A Flegel; Connie M Westhoff; Gregory A Denomme; Meghan Delaney; Margaret A Keller; Susan T Johnson; Louis Katz; John T Queenan; Ralph R Vassallo; Clayton D Simon
Journal:  Transfusion       Date:  2014-12-01       Impact factor: 3.157

9.  Molecular typing for blood group antigens within 40 min by direct polymerase chain reaction from plasma or serum.

Authors:  Franz F Wagner; Willy A Flegel; Rita Bittner; Andrea Döscher
Journal:  Br J Haematol       Date:  2016-12-19       Impact factor: 6.998

10.  Red cell alloimmunisation: incidence and prevention.

Authors:  Willy Albert Flegel
Journal:  Lancet Haematol       Date:  2016-05-09       Impact factor: 18.959

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