Literature DB >> 2111286

Inhibition of Rickettsia conorii growth by recombinant tumor necrosis factor alpha: enhancement of inhibition by gamma interferon.

E Manor1, I Sarov.   

Abstract

Purified human recombinant tumor necrosis factor alpha (rTNF-alpha) inhibited the growth of Rickettsia conorii (Casablanca strain) in HEp-2 cell culture. The effect was observed when the cells were pretreated with rTNF-alpha or when rTNF-alpha was added after adsorption of the rickettsiae. The inhibitory effect of rTNF-alpha on rickettsial growth was enhanced by gamma interferon. Cycloheximide had no effect on inhibition of the rickettsial yield, suggesting that de novo protein synthesis is not required for the inhibitory effect of rTNF-alpha. The addition of tryptophan partially abolished the inhibitory effect of rTNF-alpha and rTNF-alpha plus gamma interferon.

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Year:  1990        PMID： 2111286      PMCID： PMC258739          DOI： 10.1128/iai.58.6.1886-1890.1990

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  23 in total

1.  [3H]Uridine uptake by target monolayers as a terminal label in an in vitro cell-mediated cytotoxicity assay.

Authors:  G Smith; S Nicklin
Journal:  J Immunol Methods       Date:  1979       Impact factor: 2.303

2.  Rickettsial vasculitis.

Authors:  D H Walker; W D Mattern
Journal:  Am Heart J       Date:  1980-12       Impact factor: 4.749

3.  Reversion of the antichlamydial effect of tumor necrosis factor by tryptophan and antibodies to beta interferon.

Authors:  Y Shemer-Avni; D Wallach; I Sarov
Journal:  Infect Immun       Date:  1989-11       Impact factor: 3.441

4.  Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection.

Authors:  D M Williams; L F Bonewald; G D Roodman; G I Byrne; D M Magee; J Schachter
Journal:  Infect Immun       Date:  1989-05       Impact factor: 3.441

5.  Malarial parasites and tumour cells are killed by the same component of tumour necrosis serum.

Authors:  J Taverne; N Matthews; P Depledge; J H Playfair
Journal:  Clin Exp Immunol       Date:  1984-08       Impact factor: 4.330

6.  Effect of mouse lymphokines and cloned mouse interferon-gamma on the interaction of Rickettsia prowazekii with mouse macrophage-like RAW264.7 cells.

Authors:  J Turco; H H Winkler
Journal:  Infect Immun       Date:  1984-08       Impact factor: 3.441

7.  Possible importance of macrophage-derived mediators in acute malaria.

Authors:  I A Clark; J L Virelizier; E A Carswell; P R Wood
Journal:  Infect Immun       Date:  1981-06       Impact factor: 3.441

8.  Differential sensitivity in vivo of lethal and nonlethal malarial parasites to endotoxin-induced serum factor.

Authors:  J Taverne; P Depledge; J H Playfair
Journal:  Infect Immun       Date:  1982-09       Impact factor: 3.441

9.  Antimicrobial resistance enhancing activity of tumor necrosis serum factor induced by endotoxin in BCG-treated mice.

Authors:  M Parant
Journal:  Recent Results Cancer Res       Date:  1980

10.  Cloned mouse interferon-gamma inhibits the growth of Rickettsia prowazekii in cultured mouse fibroblasts.

Authors:  J Turco; H H Winkler
Journal:  J Exp Med       Date:  1983-12-01       Impact factor: 14.307
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  15 in total

Review 1.  Recent molecular insights into rickettsial pathogenesis and immunity.

Authors:  Sanjeev K Sahni; Hema P Narra; Abha Sahni; David H Walker
Journal:  Future Microbiol       Date:  2013-10       Impact factor: 3.165

2.  Both inducible nitric oxide synthase and NADPH oxidase contribute to the control of virulent phase I Coxiella burnetii infections.

Authors:  Robert E Brennan; Kasi Russell; Guoquan Zhang; James E Samuel
Journal:  Infect Immun       Date:  2004-11       Impact factor: 3.441

3.  Inhibition of Legionella pneumophila growth by gamma interferon in permissive A/J mouse macrophages: role of reactive oxygen species, nitric oxide, tryptophan, and iron(III).

Authors:  S J Gebran; Y Yamamoto; C Newton; T W Klein; H Friedman
Journal:  Infect Immun       Date:  1994-08       Impact factor: 3.441

4.  Rickettsia australis infection: a murine model of a highly invasive vasculopathic rickettsiosis.

Authors:  H M Feng; J Wen; D H Walker
Journal:  Am J Pathol       Date:  1993-05       Impact factor: 4.307

5.  Susceptibility of Rickettsia tsutsugamushi Gilliam to gamma interferon in cultured mouse cells.

Authors:  B Hanson
Journal:  Infect Immun       Date:  1991-11       Impact factor: 3.441

6.  Depletion of gamma interferon and tumor necrosis factor alpha in mice with Rickettsia conorii-infected endothelium: impairment of rickettsicidal nitric oxide production resulting in fatal, overwhelming rickettsial disease.

Authors:  H M Feng; V L Popov; D H Walker
Journal:  Infect Immun       Date:  1994-05       Impact factor: 3.441

7.  Interferon-gamma and tumor necrosis factor-alpha exert their antirickettsial effect via induction of synthesis of nitric oxide.

Authors:  H M Feng; D H Walker
Journal:  Am J Pathol       Date:  1993-10       Impact factor: 4.307

8.  Role of the nitric oxide synthase pathway in inhibition of growth of interferon-sensitive and interferon-resistant Rickettsia prowazekii strains in L929 cells treated with tumor necrosis factor alpha and gamma interferon.

Authors:  J Turco; H H Winkler
Journal:  Infect Immun       Date:  1993-10       Impact factor: 3.441

Review 9.  Host-cell interactions with pathogenic Rickettsia species.

Authors:  Sanjeev K Sahni; Elena Rydkina
Journal:  Future Microbiol       Date:  2009-04       Impact factor: 3.165

10.  Relationship of tumor necrosis factor alpha, the nitric oxide synthase pathway, and lipopolysaccharide to the killing of gamma interferon-treated macrophage-like RAW264.7 cells by Rickettsia prowazekii.

Authors:  J Turco; H H Winkler
Journal:  Infect Immun       Date:  1994-06       Impact factor: 3.441
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