Literature DB >> 21111812

What's Nu(SAP) in mitosis and cancer?

Jyoti Iyer1, Saili Moghe, Manabu Furukawa, Ming-Ying Tsai.   

Abstract

Unperturbed mitosis is a prerequisite for the generation of two genetically identical daughter cells. Nucleolar-spindle associated protein (NuSAP) is an important mitotic regulator. The activity of NuSAP is essential for a variety of cellular events that occur during mitosis starting from spindle assembly to cytokinesis. In addition to playing crucial roles during mitosis, NuSAP has been in the spotlight recently due to different studies exhibiting its importance in embryogenesis and cancer. In this review, we have extensively mined the current literature and made connections between different studies involving NuSAP. Importantly, we have assembled data pertaining to NuSAP from several proteomic studies and analyzed it thoroughly. Our review focuses on the role of NuSAP in mitosis and cancer, and brings to light several unanswered questions regarding the regulation of NuSAP in mitosis and its role in carcinogenesis.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 21111812     DOI： 10.1016/j.cellsig.2010.11.006

Source DB:  PubMed          Journal:  Cell Signal        ISSN： 0898-6568            Impact factor:   4.315


  26 in total

1.  Identification of castration-dependent and -independent driver genes and pathways in castration-resistant prostate cancer (CRPC).

Authors:  Yan Li; Hui Shi; Zhenjun Zhao; Minghui Xu
Journal:  BMC Urol       Date:  2022-10-18       Impact factor: 2.090

2.  Nucleolar and spindle-associated protein 1 is a tumor grade correlated prognosis marker for glioma patients.

Authors:  Tao Zhu; Pan Xie; Yuan-Feng Gao; Ma-Sha Huang; Xi Li; Wei Zhang; Hong-Hao Zhou; Zhao-Qian Liu
Journal:  CNS Neurosci Ther       Date:  2018-01-15       Impact factor: 5.243

3.  Transcriptome profiling reveals PDZ binding kinase as a novel biomarker in peritumoral brain zone of glioblastoma.

Authors:  Banavathy S Kruthika; Ruchi Jain; A Arivazhagan; R D Bharath; T C Yasha; Paturu Kondaiah; Vani Santosh
Journal:  J Neurooncol       Date:  2018-11-20       Impact factor: 4.130

4.  Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1.

Authors:  Z G Gulzar; J K McKenney; J D Brooks
Journal:  Oncogene       Date:  2012-02-20       Impact factor: 9.867

5.  High Levels of Nucleolar Spindle-Associated Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in Triple-Negative Breast Cancer.

Authors:  Li Chen; Liu Yang; Feng Qiao; Xin Hu; Shan Li; Ling Yao; Xue-Li Yang; Zhi-Ming Shao
Journal:  PLoS One       Date:  2015-10-20       Impact factor: 3.240

6.  Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas.

Authors:  Misu Lee; Ilaria Marinoni; Martin Irmler; Tsambika Psaras; Jürgen B Honegger; Rudi Beschorner; Natasa Anastasov; Johannes Beckers; Marily Theodoropoulou; Federico Roncaroli; Natalia S Pellegata
Journal:  Acta Neuropathol       Date:  2013-06-12       Impact factor: 17.088

7.  TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys.

Authors:  Christa E Osuna; Ana Maria Gonzalez; Hsun-Hsien Chang; Amy Shi Hung; Elizabeth Ehlinger; Kara Anasti; S Munir Alam; Norman L Letvin
Journal:  PLoS Pathog       Date:  2014-04-17       Impact factor: 6.823

8.  NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force.

Authors:  Chenyu Li; Chenyi Xue; Qiaoyun Yang; Boon Chuan Low; Yih-Cherng Liou
Journal:  Nat Commun       Date:  2016-02-03       Impact factor: 14.919

9.  Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.

Authors:  Atsushi Okamoto; Morihiro Higo; Masashi Shiiba; Dai Nakashima; Tomoyoshi Koyama; Isao Miyamoto; Hiroki Kasama; Atsushi Kasamatsu; Katsunori Ogawara; Hidetaka Yokoe; Hideki Tanzawa; Katsuhiro Uzawa
Journal:  PLoS One       Date:  2015-11-10       Impact factor: 3.240

10.  NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity.

Authors:  Chenyu Li; Yajun Zhang; Qiaoyun Yang; Fan Ye; Stella Ying Sun; Ee Sin Chen; Yih-Cherng Liou
Journal:  Sci Rep       Date:  2016-01-06       Impact factor: 4.379
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