Literature DB >> 2111172

Feedback regulation of platelet function by 12S-hydroxyeicosatetraenoic acid: inhibition of arachidonic acid liberation from phospholipids.

F Sekiya1, J Takagi, K Sasaki, K Kawajiri, Y Kobayashi, F Sato, Y Saito.   

Abstract

We have proposed a mechanism that platelet aggregation is regulated by its 12-lipoxygenase product, 12S-hydroxyeicosatetraenoic acid (12-HETE) (Sekiya, F., Takagi, J. and Saito, Y. (1989) Thrombos. Res. 56, 407-415). Inhibition of endogenous 12-HETE production by 15-HETE, a specific inhibitor of 12-lipoxygenase, accelerated aggregation of bovine platelets in response to collagen and arachidonic acid liberation from phospholipids was enhanced. Exogenously added 12-HETE suppressed collagen-induced liberation of arachidonic acid and the aggregation was also inhibited. On the other hand, 12-HETE did not interfere with thromboxane synthesis from free arachidonic acid in a cell-free system. These observations suggest that 12-HETE exerts a negative feedback to prevent excess aggregation through interference with arachidonic acid liberation from membrane phospholipids.

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Year:  1990        PMID： 2111172     DOI： 10.1016/0005-2760(90)90232-m

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  An anti-platelet agent, OPC-29030, inhibits translocation of 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid production in human platelets.

Authors:  Y Ozeki; Y Nagamura; H Ito; F Unemi; Y Kimura; T Igawa; J i Kambayashi; Y Takahashi; T Yoshimoto
Journal:  Br J Pharmacol       Date:  1999-12       Impact factor: 8.739

Review 2.  Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs.

Authors:  Melissa Gabbs; Shan Leng; Jessay G Devassy; Md Monirujjaman; Harold M Aukema
Journal:  Adv Nutr       Date:  2015-09-15       Impact factor: 8.701

Review 3.  The expansive role of oxylipins on platelet biology.

Authors:  Jennifer Yeung; Megan Hawley; Michael Holinstat
Journal:  J Mol Med (Berl)       Date:  2017-05-20       Impact factor: 4.599

4.  Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPARdelta/PGE2 and elevation of PGE3.

Authors:  J Vanamala; A Glagolenko; P Yang; R J Carroll; M E Murphy; R A Newman; J R Ford; L A Braby; R S Chapkin; N D Turner; J R Lupton
Journal:  Carcinogenesis       Date:  2007-11-16       Impact factor: 4.944

5.  Roles of arachidonic acid, lipoxygenases and phosphatases in calcium-dependent modulation of M-current in bullfrog sympathetic neurons.

Authors:  S P Yu
Journal:  J Physiol       Date:  1995-09-15       Impact factor: 5.182

6.  Decreased arachidonic acid metabolism in human platelets by autologous neutrophils: possible role of cell adhesion.

Authors:  B Chabannes; P Molière; Y Pacheco; M Lagarde
Journal:  Biochem J       Date:  1994-06-15       Impact factor: 3.857

7.  12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition.

Authors:  Benjamin H Maskrey; Gordon F Rushworth; Matthew H Law; Andrew T Treweeke; Jun Wei; Stephen J Leslie; Ian L Megson; Phillip D Whitfield
Journal:  J Inflamm (Lond)       Date:  2014-10-23       Impact factor: 4.981

Review 8.  The emerging role of oxylipins in thrombosis and diabetes.

Authors:  Benjamin E Tourdot; Intekhab Ahmed; Michael Holinstat
Journal:  Front Pharmacol       Date:  2014-01-07       Impact factor: 5.810

9.  Differential proteomic analysis of platelets suggested target-related proteins in rabbit platelets treated with Rhizoma Corydalis.

Authors:  Chun-Hong Li; Cen Chen; Qian Zhang; Chen-Ning Tan; Yuan-Jia Hu; Peng Li; Jian-Bo Wan; Gang Feng; Zhi-Ning Xia; Feng-Qing Yang
Journal:  Pharm Biol       Date:  2016-09-22       Impact factor: 3.503
  9 in total

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