Literature DB >> 21110823

Bcl-2 targeted-therapy for the treatment of head and neck squamous cell carcinoma.

Lucas V dos Santos1, André L Carvalho.   

Abstract

Despite recent advances in treatment of head and neck cancer, survival has not improved as expected. Bcl-2 family proteins play important role in regulating apoptosis. Recently, newer molecules have been developed for inhibition of Bcl-2 related proteins. We, herein aim to discuss the importance of Bcl-2 family proteins to the development of head and neck cancer and how the targeted-therapy for inhibition of Bcl-2 and related proteins, based on new drugs and recent patents, could improve the efficacy of the systemic therapy.

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Year:  2011        PMID： 21110823     DOI： 10.2174/157489211793980042

Source DB:  PubMed          Journal:  Recent Pat Anticancer Drug Discov        ISSN： 1574-8928            Impact factor:   4.169


  7 in total

1.  BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma.

Authors:  Gerson A Acasigua; Kristy A Warner; Felipe Nör; Joseph Helman; Alexander T Pearson; Anna C Fossati; Shaomeng Wang; Jacques E Nör
Journal:  Oral Oncol       Date:  2015-06-26       Impact factor: 5.337

2.  Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrion-cytochrome c-caspase protease pathway.

Authors:  Jia-Wei Lin; Juei-Tai Chen; Chung-Ye Hong; Yi-Ling Lin; Kuan-Ting Wang; Chih-Jung Yao; Gi-Ming Lai; Ruei-Ming Chen
Journal:  Neuro Oncol       Date:  2012-01-18       Impact factor: 12.300

3.  Synergistic combination of small molecule inhibitor and RNA interference against antiapoptotic Bcl-2 protein in head and neck cancer cells.

Authors:  Yen-Ling Lin; Yasemin Yuksel Durmaz; Jacques E Nör; Mohamed E H ElSayed
Journal:  Mol Pharm       Date:  2013-06-18       Impact factor: 4.939

4.  A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma.

Authors:  Luca D'Agostino; Antonio Giordano
Journal:  Oncotarget       Date:  2011-12

5.  Challenges in organizing effective oncology service: inter-European variability in the example of head and neck cancers.

Authors:  Julian Malicki; Wojciech Golusinski
Journal:  Eur Arch Otorhinolaryngol       Date:  2014-07-22       Impact factor: 2.503

6.  Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck.

Authors:  Rachel J Carter; Mateus Milani; Michael Butterworth; Ahoud Alotibi; Nicholas Harper; Govindaraju Yedida; Georgia Greaves; Aoula Al-Zebeeby; Andrea L Jorgensen; Andrew G Schache; Janet M Risk; Richard J Shaw; Terry M Jones; Joseph J Sacco; Adam Hurlstone; Gerald M Cohen; Shankar Varadarajan
Journal:  Cell Death Dis       Date:  2019-12-04       Impact factor: 8.469

7.  Silencing bcl-2 expression in epithelial cancer cells using "smart" particles.

Authors:  Yen-Ling Lin; Guohua Jiang; Zhaocheng Zhang; Jacques E Nör; Mohamed E H ElSayed
Journal:  J Funct Biomater       Date:  2014-09-16
  7 in total

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