| Literature DB >> 21109188 |
Marc Chatenay-Lapointe1, Gerald S Shadel.
Abstract
Mechanisms maintaining mitochondrial integrity range from specific repair pathways to wholesale degradation of damaged organelles. A recent study in Molecular Cell (Heo et al., 2010) adds another mechanism to this mitochondrial homeostasis toolkit: mitochondria-associated protein degradation (MAD) that ultimately directs endoplasmic reticulum-associated protein degradation (ERAD) pathway components to oxidatively stressed mitochondria.Entities:
Year: 2010 PMID: 21109188 PMCID: PMC3018381 DOI: 10.1016/j.cmet.2010.11.018
Source DB: PubMed Journal: Cell Metab ISSN: 1550-4131 Impact factor: 27.287