Literature DB >> 211090

Some properties of beta-toxin produced by Clostridium perfringens type C.

J Sakurai, C L Duncan.   

Abstract

Purified beta-toxin from Clostridium perfringens type C was found to be a single polypeptide chain protein with a molecular weight of approximately 30,000. The toxin was heat labile, with 75% of its activity being inactivated by incubation at 50 degrees C for 5 min. Biological activity of the purified toxin was completely destroyed on exposure to trypsin for 30 min at 37 degrees C. The 50% lethal dose for mice was 1.87 microgram of purified toxin.

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Year:  1978        PMID： 211090      PMCID： PMC422049          DOI： 10.1128/iai.21.2.678-680.1978

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  7 in total

1.  EFFECT OF PH ON TOXINOGENESIS BY CLOSTRIDIUM PERFRINGENS TYPE C.

Authors:  H PIVNICK; A F HABEEB; B GORENSTEIN; P F STUART; A H HAUSCHILD
Journal:  Can J Microbiol       Date:  1964-06       Impact factor: 2.419

2.  Purification of beta-toxin from Clostridium perfringens type C.

Authors:  J Sakurai; C L Duncan
Journal:  Infect Immun       Date:  1977-12       Impact factor: 3.441

3.  [Preliminary data on the purification and structure of Clostridium perfringens alpha-toxin].

Authors:  G Teodorescu; J Bittner; A Ceacăreanu
Journal:  Arch Roum Pathol Exp Microbiol       Date:  1970-09

4.  Purification of phospholipase C (alpha-toxin) from Clostridium perfringens.

Authors:  R Möllby; T Wadström
Journal:  Biochim Biophys Acta       Date:  1973-10-10

5.  Cereolysin: production, purification and partial characterization.

Authors:  A W Bernheimer; P Grushoff
Journal:  J Gen Microbiol       Date:  1967-01

6.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

7.  Estimation of the molecular weights of proteins by Sephadex gel-filtration.

Authors:  P Andrews
Journal:  Biochem J       Date:  1964-05       Impact factor: 3.766
  7 in total
  25 in total

Review 1.  Recent progress in understanding the pathogenesis of Clostridium perfringens type C infections.

Authors:  F A Uzal; B A McClane
Journal:  Vet Microbiol       Date:  2011-02-26       Impact factor: 3.293

2.  Identification and characterization of Clostridium perfringens beta toxin variants with differing trypsin sensitivity and in vitro cytotoxicity activity.

Authors:  James R Theoret; Francisco A Uzal; Bruce A McClane
Journal:  Infect Immun       Date:  2015-02-02       Impact factor: 3.441

Review 3.  Comparative pathogenesis of enteric clostridial infections in humans and animals.

Authors:  Francisco A Uzal; Mauricio A Navarro; Jihong Li; John C Freedman; Archana Shrestha; Bruce A McClane
Journal:  Anaerobe       Date:  2018-06-05       Impact factor: 3.331

4.  Clostridium perfringens beta-toxin forms potential-dependent, cation-selective channels in lipid bilayers.

Authors:  O Shatursky; R Bayles; M Rogers; B H Jost; J G Songer; R K Tweten
Journal:  Infect Immun       Date:  2000-10       Impact factor: 3.441

5.  Characterization of Clostridium perfringens TpeL toxin gene carriage, production, cytotoxic contributions, and trypsin sensitivity.

Authors:  Jianming Chen; Bruce A McClane
Journal:  Infect Immun       Date:  2015-03-30       Impact factor: 3.441

6.  The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build Clostridium perfringens biofilms.

Authors:  Jorge E Vidal; Joshua R Shak; Adrian Canizalez-Roman
Journal:  Infect Immun       Date:  2015-03-30       Impact factor: 3.441

7.  Both epsilon-toxin and beta-toxin are important for the lethal properties of Clostridium perfringens type B isolates in the mouse intravenous injection model.

Authors:  Mariano E Fernandez-Miyakawa; Derek J Fisher; Rachael Poon; Sameera Sayeed; Vicki Adams; Julian I Rood; Bruce A McClane; Francisco A Uzal
Journal:  Infect Immun       Date:  2007-01-08       Impact factor: 3.441

8.  Experimental pigbel: the production and pathology of necrotizing enteritis due to Clostridium welchii type C in the guinea-pig.

Authors:  G Lawrence; R Cooke
Journal:  Br J Exp Pathol       Date:  1980-06

Review 9.  Clostridium perfringens in animal disease: a review of current knowledge.

Authors:  L Niilo
Journal:  Can Vet J       Date:  1980-05       Impact factor: 1.008

10.  Effects of Clostridium perfringens beta-toxin on the rabbit small intestine and colon.

Authors:  Jorge E Vidal; Bruce A McClane; Juliann Saputo; Jaquelyn Parker; Francisco A Uzal
Journal:  Infect Immun       Date:  2008-07-14       Impact factor: 3.441
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