BACKGROUND: Approximately 20-30% of patients with psoriasis treated with anti-tumour necrosis factor α (TNFα) agents will discontinue treatment within 2 years due to loss of efficacy or side-effects. Switching to another anti-TNFα agent produces clinical responses inferior to previously untreated patients. Ustekinumab binds to the p40 subunit of interleukin (IL)-12 and IL-23 and provides a mechanism of action independent of TNFα. OBJECTIVE: To investigate the efficacy of ustekinumab in a clinical practice setting and to compare treatment responses to ustekinumab in patients previously treated with TNFα inhibitors and anti-TNFα-naïve patients. METHODS: Patients receiving either ustekinumab (n=71) or the subcutaneous TNFα inhibitors adalimumab or etanercept (n=108) were identified through the registry of psoriasis patients in our Institutions. Efficacy effect outcome was a 75% improvement in the psoriasis area severity index (PASI75). Kaplan-Meier statistics evaluated the adherence to the treatments expressed as drug survival rate. RESULTS: PASI75 was achieved in 80% of the ustekinumab-treated patients after a median time of 112 days. There was no difference in efficacy in anti-TNFα-naïve patients compared with anti-TNFα unresponsive patients. Patients treated with ustekinumab showed a superior adherence to treatment in comparison with adalimumab and etanercept. LIMITATIONS: Patients were non-randomly assigned to treatment, which potentially may lead to biases. Observation time was short (1 year). CONCLUSION: In clinical practice, the short-term efficacy and patient adherence to ustekinumab are excellent and comparable to the data obtained in clinical trials. Lack of response to previous anti-TNF treatment does not impair clinical response to ustekinumab.
BACKGROUND: Approximately 20-30% of patients with psoriasis treated with anti-tumour necrosis factor α (TNFα) agents will discontinue treatment within 2 years due to loss of efficacy or side-effects. Switching to another anti-TNFα agent produces clinical responses inferior to previously untreated patients. Ustekinumab binds to the p40 subunit of interleukin (IL)-12 and IL-23 and provides a mechanism of action independent of TNFα. OBJECTIVE: To investigate the efficacy of ustekinumab in a clinical practice setting and to compare treatment responses to ustekinumab in patients previously treated with TNFα inhibitors and anti-TNFα-naïve patients. METHODS:Patients receiving either ustekinumab (n=71) or the subcutaneous TNFα inhibitors adalimumab or etanercept (n=108) were identified through the registry of psoriasispatients in our Institutions. Efficacy effect outcome was a 75% improvement in the psoriasis area severity index (PASI75). Kaplan-Meier statistics evaluated the adherence to the treatments expressed as drug survival rate. RESULTS: PASI75 was achieved in 80% of the ustekinumab-treated patients after a median time of 112 days. There was no difference in efficacy in anti-TNFα-naïve patients compared with anti-TNFα unresponsive patients. Patients treated with ustekinumab showed a superior adherence to treatment in comparison with adalimumab and etanercept. LIMITATIONS: Patients were non-randomly assigned to treatment, which potentially may lead to biases. Observation time was short (1 year). CONCLUSION: In clinical practice, the short-term efficacy and patient adherence to ustekinumab are excellent and comparable to the data obtained in clinical trials. Lack of response to previous anti-TNF treatment does not impair clinical response to ustekinumab.
Authors: Ireny Y K Iskandar; Richard B Warren; Mark Lunt; Kayleigh J Mason; Ian Evans; Kathleen McElhone; Catherine H Smith; Nick J Reynolds; Darren M Ashcroft; Christopher E M Griffiths Journal: J Invest Dermatol Date: 2017-12-06 Impact factor: 7.590
Authors: Andrew Blauvelt; Kim A Papp; Christopher E M Griffiths; Luis Puig; Jamie Weisman; Yves Dutronc; Lisa Farmer Kerr; Dapo Ilo; Lotus Mallbris; Matthias Augustin Journal: Am J Clin Dermatol Date: 2017-04 Impact factor: 7.403
Authors: I Y K Iskandar; D M Ashcroft; R B Warren; M Lunt; K McElhone; C H Smith; N J Reynolds; C E M Griffiths Journal: Br J Dermatol Date: 2017-10-19 Impact factor: 9.302
Authors: A Menter; K A Papp; M Gooderham; D M Pariser; M Augustin; F A Kerdel; S Fakharzadeh; K Goyal; S Calabro; W Langholff; S Chavers; D Naessens; J Sermon; G G Krueger Journal: J Eur Acad Dermatol Venereol Date: 2016-03-30 Impact factor: 6.166