Literature DB >> 2110847

Amyloid beta-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia.

M Shoji1, S Hirai, H Yamaguchi, Y Harigaya, T Kawarabayashi.   

Abstract

We raised two rabbit antisera against synthetic peptides corresponding to the carboxyl- and amino-terminal regions of the predicted amyloid beta-protein precursor (APP). Both antisera recognized the same 106-135 kDa proteins of human brain extract by immunoblot analysis. Immunocytochemical studies showed that these antisera both reacted with the same dystrophic neurites within the senile plaques of Alzheimer brains. These results indicated that APP accumulated in the dystrophic neurites of the senile plaques.

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Year:  1990        PMID： 2110847     DOI： 10.1016/0006-8993(90)91187-l

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  27 in total

1.  Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives.

Authors:  Qinxi Guo; Hongmei Li; Samson S K Gaddam; Nicholas J Justice; Claudia S Robertson; Hui Zheng
Journal:  J Biol Chem       Date:  2011-12-05       Impact factor: 5.157

2.  Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.

Authors:  H Yamaguchi; Y Nakazato; M Shoji; K Okamoto; Y Ihara; M Morimatsu; S Hirai
Journal:  Am J Pathol       Date:  1991-03       Impact factor: 4.307

3.  Alzheimer amyloid beta-protein precursor in sperm development.

Authors:  M Shoji; T Kawarabayashi; Y Harigaya; H Yamaguchi; S Hirai; T Kamimura; T Sugiyama
Journal:  Am J Pathol       Date:  1990-11       Impact factor: 4.307

4.  Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia.

Authors:  H Yamaguchi; Y Nakazato; T Kawarabayashi; K Ishiguro; Y Ihara; M Morimatsu; S Hirai
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088

5.  Alzheimer's amyloid precursor protein-positive degenerative neurites exist even within kuru plaques not specific to Alzheimer's disease.

Authors:  T Ohgami; T Kitamoto; A Weidmann; K Beyreuther; J Tateishi
Journal:  Am J Pathol       Date:  1991-12       Impact factor: 4.307

Review 6.  Distribution of beta/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease.

Authors:  A J Rozemuller; R A Roos; G T Bots; W Kamphorst; P Eikelenboom; W E Van Nostrand
Journal:  Am J Pathol       Date:  1993-05       Impact factor: 4.307

7.  Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities.

Authors:  Xiangyou Hu; Qi Shi; Xiangdong Zhou; Wanxia He; Hong Yi; Xinghua Yin; Marla Gearing; Allan Levey; Riqiang Yan
Journal:  EMBO J       Date:  2007-05-03       Impact factor: 11.598

8.  Distribution of neuronal growth-promoting factors and cytoskeletal proteins in altered neurites in Alzheimer's disease and non-demented elderly.

Authors:  S S Zhan; W Kamphorst; W E Van Nostrand; P Eikelenboom
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

9.  The occurrence of aging-dependent reticulon 3 immunoreactive dystrophic neurites decreases cognitive function.

Authors:  Qi Shi; Xiangyou Hu; Marguerite Prior; Riqiang Yan
Journal:  J Neurosci       Date:  2009-04-22       Impact factor: 6.167

10.  Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.

Authors:  P Cras; M Kawai; D Lowery; P Gonzalez-DeWhitt; B Greenberg; G Perry
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205
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