Literature DB >> 2110845

Restoration of cholinomimetic activity by clonidine in cholinergic plus noradrenergic lesioned rats.

V Haroutunian1, P D Kanof, G Tsuboyama, K L Davis.   

Abstract

The effects of combined lesions of forebrain cholinergic and noradrenergic systems on memory and responsivity to the memory enhancing effects of cholinomimetics were investigated in rats. Forebrain noradrenergic deficits produced by the injection of 6-hydroxydopamine into the ascending noradrenergic bundle (ANB) blocked the ability of cholinomimetics such as physostigmine and oxotremorine to enhance retention test performance in nucleus basalis of Meynert lesioned rats. Low doses of the noradrenergic receptor agonist clonidine, when administered in conjunction with cholinomimetics reversed this blockade. These results suggest that combined cholinergic/noradrenergic therapy may be of value in the treatment of some Alzheimer's disease patients.

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Year:  1990        PMID： 2110845     DOI： 10.1016/0006-8993(90)90280-o

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

Review 1.  Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I.

Authors:  M Sarter; J Hagan; P Dudchenko
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  Effect of acute and chronic cholinesterase inhibition on biogenic amines in rat brain.

Authors:  H Soininen; L Unni; S Shillcutt
Journal:  Neurochem Res       Date:  1990-12       Impact factor: 3.996

Review 3.  Diagnostic and pharmacological approaches in Alzheimer's disease.

Authors:  C Hermann; R G Stern; M F Losonzcy; S Jaff; M Davidson
Journal:  Drugs Aging       Date:  1991-03       Impact factor: 3.923

Review 4.  Adrenergic targets for the treatment of cognitive deficits in schizophrenia.

Authors:  Amy F T Arnsten
Journal:  Psychopharmacology (Berl)       Date:  2003-12-19       Impact factor: 4.530

5.  Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation.

Authors:  W Wallace; S T Ahlers; J Gotlib; V Bragin; J Sugar; R Gluck; P A Shea; K L Davis; V Haroutunian
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205

6.  Alpha 2-adrenoceptor antagonists potentiate acetylcholinesterase inhibitor effects on passive avoidance learning in the rat.

Authors:  F Camacho; C P Smith; H M Vargas; J T Winslow
Journal:  Psychopharmacology (Berl)       Date:  1996-04       Impact factor: 4.530

7.  The effect of treadmill running on passive avoidance learning in animal model of Alzheimer disease.

Authors:  Nasrin Hosseini; Hojjatallah Alaei; Parham Reisi; Maryam Radahmadi
Journal:  Int J Prev Med       Date:  2013-02
  7 in total

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