Genetic polymorphisms of glutathione S-transferase Z1 in an Iranian population.

Genetic polymorphisms in gene encoding glutathione S-transferase Z1 (GSTZ1, a member of class zeta) have been defined. Previous studies have revealed that there was significant difference between populations for allelic frequency of several members of GSTs. In order to get more insight into the genetic structure of Iranian population the present study was done on Iranian Persian population who living in Shiraz (Fars province). The total study subjects consisted of 689 unrelated healthy individuals. Genetic polymorphisms for G-1002A, Glu32Lys and Gly42Arg of the GSTZ1 were detected by RFLP-PCR-based method. Allelic frequency of 32Lys, 42Arg, and -1002G was 0.2337, 0.0298 and 0.2184, respectively. The study population was at Hardy-Weinberg equilibrium for the polymorphisms of GSTZ1. Based on the complete dataset, these polymorphisms show significant linkage disequilibrium. Iranian gene pool showed intermediate frequency for alleles and haplotypes of GSTZ1 polymorphisms in comparison with European and Asian countries, which confirmed our previous reports for other genetic polymorphisms.