Literature DB >> 21107720

The effects of simvastatin on angiogenesis: studied by an original model of atherosclerosis and acute myocardial infarction in rabbit.

Wei Shen1, Hai-Ming Shi, Wei-Hu Fan, Xin-Ping Luo, Bo Jin, Yong Li.   

Abstract

Statins have shown pleiotropic effects, many of them independent of their impact on lipids. Angiogenesis can be beneficial in the acute myocardial infarction to improve circulation. However, it also can be harmful due to worsening of atherosclerosis. Here, we established a new minimal invasive rabbit model to study ischemic myocardium and atherosclerosis together to mimic clinical scenario. We demonstrated that simvastatin has the effect of pro-angiogenesis and further improve cardiac function in ischemic myocardium, as well as the effect of anti-angiogenesis to improve atherosclerosis in aorta vessels.

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Year:  2010        PMID： 21107720     DOI： 10.1007/s11033-010-0497-0

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  44 in total

1.  Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-alpha via inhibition of the protein kinase C signaling pathway.

Authors:  Réjane Paumelle; Christophe Blanquart; Olivier Briand; Olivier Barbier; Christian Duhem; Gaëtane Woerly; Frédéric Percevault; Jean-Charles Fruchart; David Dombrowicz; Corine Glineur; Bart Staels
Journal:  Circ Res       Date:  2006-01-05       Impact factor: 17.367

Review 2.  Statins: a new insight into their mechanisms of action and consequent pleiotropic effects.

Authors:  Magdalena Jasińska; Jacek Owczarek; Daria Orszulak-Michalak
Journal:  Pharmacol Rep       Date:  2007 Sep-Oct       Impact factor: 3.024

Review 3.  Besides adhesion: new perspectives of integrin functions in angiogenesis.

Authors:  Guido Serini; Lucia Napione; Marco Arese; Federico Bussolino
Journal:  Cardiovasc Res       Date:  2008-02-19       Impact factor: 10.787

4.  Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol.

Authors:  Galina K Sukhova; J Koudy Williams; Peter Libby
Journal:  Arterioscler Thromb Vasc Biol       Date:  2002-09-01       Impact factor: 8.311

Review 5.  Statin safety: an overview and assessment of the data--2005.

Authors:  Harold Bays
Journal:  Am J Cardiol       Date:  2006-02-08       Impact factor: 2.778

6.  Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability.

Authors:  Marika Massaro; Antonella Zampolli; Egeria Scoditti; Maria Annunziata Carluccio; Carlo Storelli; Alessandro Distante; Raffaele De Caterina
Journal:  Cardiovasc Res       Date:  2009-11-27       Impact factor: 10.787

7.  Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase.

Authors:  Ulf Landmesser; Niels Engberding; Ferdinand H Bahlmann; Arnd Schaefer; Antje Wiencke; Andre Heineke; Stephan Spiekermann; Denise Hilfiker-Kleiner; Christian Templin; Daniel Kotlarz; Maja Mueller; Martin Fuchs; Burkhard Hornig; Hermann Haller; Helmut Drexler
Journal:  Circulation       Date:  2004-10-05       Impact factor: 29.690

8.  Effect of simvastatin on culturing of kidney cells from pigs in vitro.

Authors:  Guifen Liu; Haichao Lin; Jinlian Fu; Aiguo Wang
Journal:  Mol Biol Rep       Date:  2009-04-03       Impact factor: 2.316

9.  HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells.

Authors:  Wolfgang Dichtl; Jozef Dulak; Matthias Frick; Hannes F Alber; Severin P Schwarzacher; Mikko P S Ares; Jan Nilsson; Otmar Pachinger; Franz Weidinger
Journal:  Arterioscler Thromb Vasc Biol       Date:  2003-01-01       Impact factor: 8.311

Review 10.  Nitric oxide mechanisms in the pathogenesis of global risk.

Authors:  R Preston Mason
Journal:  J Clin Hypertens (Greenwich)       Date:  2006-08       Impact factor: 3.738
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  6 in total

1.  Long-term statin use before primary percutaneous coronary intervention improves treatment outcomes of acute myocardial infarction.

Authors:  Ruiwei Guo; Lixia Yang; Lihua Mu; Xianfeng Pan; Feng Qi
Journal:  Exp Ther Med       Date:  2017-02-22       Impact factor: 2.447

Review 2.  Vasa vasorum in atherosclerosis and clinical significance.

Authors:  Junyan Xu; Xiaotong Lu; Guo-Ping Shi
Journal:  Int J Mol Sci       Date:  2015-05-20       Impact factor: 5.923

3.  Atorvastatin Therapy Modulates Telomerase Activity in Patients Free of Atherosclerotic Cardiovascular Diseases.

Authors:  Irina D Strazhesko; Olga N Tkacheva; Dariga U Akasheva; Ekaterina N Dudinskaya; Ekaterina V Plokhova; Valentina S Pykhtina; Anna S Kruglikova; Natalia V Kokshagina; Natalia V Sharashkina; Mikhail V Agaltsov; Daria A Kashtanova; Vladimir A Vygodin; Irina N Ozerova; Dmitry A Skvortsov; Daria Vasilkova; Sergey A Boytsov
Journal:  Front Pharmacol       Date:  2016-09-30       Impact factor: 5.810

4.  Reciprocal regulation of eNOS, H2S and CO-synthesizing enzymes in human atheroma: Correlation with plaque stability and effects of simvastatin.

Authors:  Fragiska Sigala; Panagiotis Efentakis; Dimitra Karageorgiadi; Konstadinos Filis; Paraskevas Zampas; Efstathios K Iliodromitis; George Zografos; Andreas Papapetropoulos; Ioanna Andreadou
Journal:  Redox Biol       Date:  2017-02-12       Impact factor: 11.799

Review 5.  Holistic Regulation of Angiogenesis with Chinese Herbal Medicines as a New Option for Coronary Artery Disease.

Authors:  Rong Yuan; Wei-Li Shi; Qi-Qi Xin; Ke-Ji Chen; Wei-Hong Cong
Journal:  Evid Based Complement Alternat Med       Date:  2018-08-13       Impact factor: 2.629

6.  Comparative Effects of Preoperative Angiotensin-converting Enzyme In-hibitor, Statin and Beta-blocker Treatment on Human Internal Mammary Artery Reactivity in Patients with Coronary Artery Disease: A Pilot Study.

Authors:  Selvinaz Dalaklioglu; Ilhan Golbasi; Caglar Ogutman
Journal:  Open Cardiovasc Med J       Date:  2013-08-23
  6 in total

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