Literature DB >> 21107493

PNAs grafted with (α/γ, R/S)-aminomethylene pendants: regio and stereo specific effects on DNA binding and improved cell uptake.

Roopa Mitra1, K N Ganesh.   

Abstract

PNAs grafted with cationic aminomethylene (am) pendants on the backbone at the glycyl (α) or ethylenediamine (γ) segments show regio (α/γ) and stereochemistry (R/S) dependent binding with complementary DNA. These are efficiently taken up by cells, with γ(S-am) aeg-PNA being the best in all properties.

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Year:  2010        PMID： 21107493     DOI： 10.1039/c0cc03988h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Synthesis of a 3-Amino-2,3-dihydropyrid-4-one and Related Heterocyclic Analogues as Mechanism-Based Inhibitors of BioA, a Pyridoxal Phosphate-Dependent Enzyme.

Authors:  Carter G Eiden; Courtney C Aldrich
Journal:  J Org Chem       Date:  2017-07-26       Impact factor: 4.354

Review 2.  Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications.

Authors:  Chaturong Suparpprom; Tirayut Vilaivan
Journal:  RSC Chem Biol       Date:  2022-03-18

3.  Cellular uptake of 2-aminopyridine-modified peptide nucleic acids conjugated with cell-penetrating peptides.

Authors:  Nikita Brodyagin; Yuka Kataoka; Ilze Kumpina; Dennis W McGee; Eriks Rozners
Journal:  Biopolymers       Date:  2021-12-16       Impact factor: 2.240

4.  Recent advances in chemical modification of Peptide nucleic acids.

Authors:  Eriks Rozners
Journal:  J Nucleic Acids       Date:  2012-09-06

5.  (α,α-dimethyl)glycyl (dmg) PNAs: achiral PNA analogs that form stronger hybrids with cDNA relative to isosequential RNA.

Authors:  Aland Gourishankar; Krishna N Ganesh
Journal:  Artif DNA PNA XNA       Date:  2012 Jan-Mar

Review 6.  Chiral peptide nucleic acids with a substituent in the N-(2-aminoethy)glycine backbone.

Authors:  Toru Sugiyama; Atsushi Kittaka
Journal:  Molecules       Date:  2012-12-27       Impact factor: 4.411

7.  Evaluating the effect of ionic strength on duplex stability for PNA having negatively or positively charged side chains.

Authors:  N Tilani S De Costa; Jennifer M Heemstra
Journal:  PLoS One       Date:  2013-03-06       Impact factor: 3.240

8.  γ Sulphate PNA (PNA S): highly selective DNA binding molecule showing promising antigene activity.

Authors:  Concetta Avitabile; Loredana Moggio; Gaetano Malgieri; Domenica Capasso; Sonia Di Gaetano; Michele Saviano; Carlo Pedone; Alessandra Romanelli
Journal:  PLoS One       Date:  2012-05-07       Impact factor: 3.240

Review 9.  Peptide nucleic acids: Advanced tools for biomedical applications.

Authors:  Anjali Gupta; Anuradha Mishra; Nidhi Puri
Journal:  J Biotechnol       Date:  2017-07-29       Impact factor: 3.307
  9 in total

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