Literature DB >> 21106946

Wnt signaling and aging-related heart disorders.

Atsuhiko T Naito1, Ichiro Shiojima, Issei Komuro.   

Abstract

Aging is associated with various heart diseases, and this may be attributable, in part, to the prolonged exposure of the heart to cardiovascular risk factors. However, aging is also associated with heart disorders such as diastolic dysfunction that are not necessarily linked to the risk factors for cardiovascular diseases. Recent studies have demonstrated a mechanistic link between Wnt signaling and premature aging or aging-related phenotypes. As a part of the review series on Wnt signaling and the cardiovascular system, we discuss here the possible involvement of Wnt signaling in aging-associated heart diseases or heart disorders.

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Year:  2010        PMID： 21106946     DOI： 10.1161/CIRCRESAHA.110.223776

Source DB:  PubMed          Journal:  Circ Res        ISSN： 0009-7330            Impact factor:   17.367


  32 in total

1.  Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency.

Authors:  Wakako Kawarazaki; Risuke Mizuno; Mitsuhiro Nishimoto; Nobuhiro Ayuzawa; Daigoro Hirohama; Kohei Ueda; Fumiko Kawakami-Mori; Shigeyoshi Oba; Takeshi Marumo; Toshiro Fujita
Journal:  J Clin Invest       Date:  2020-08-03       Impact factor: 14.808

Review 2.  Update on Wnt signaling in bone cell biology and bone disease.

Authors:  David G Monroe; Meghan E McGee-Lawrence; Merry Jo Oursler; Jennifer J Westendorf
Journal:  Gene       Date:  2011-11-03       Impact factor: 3.688

3.  Loss of secreted frizzled-related protein-1 leads to deterioration of cardiac function in mice and plays a role in human cardiomyopathy.

Authors:  Piotr Sklepkiewicz; Takayuki Shiomi; Rajbir Kaur; Jie Sun; Susan Kwon; Becky Mercer; Peter Bodine; Ralph Theo Schermuly; Isaac George; P Christian Schulze; Jeanine M D'Armiento
Journal:  Circ Heart Fail       Date:  2015-02-10       Impact factor: 8.790

4.  Variegated expression of Hsp22 transgenic reporters indicates cell-specific patterns of aging in Drosophila oenocytes.

Authors:  John Tower; Gary Landis; Rebecca Gao; Albert Luan; Jonathan Lee; Yuanyue Sun
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2013-05-30       Impact factor: 6.053

5.  A microRNA switch controls dietary restriction-induced longevity through Wnt signaling.

Authors:  Yunpeng Xu; Zhidong He; Mengjiao Song; Yifei Zhou; Yidong Shen
Journal:  EMBO Rep       Date:  2019-03-14       Impact factor: 8.807

Review 6.  Insight into atrial fibrillation through analysis of the coding transcriptome in humans.

Authors:  Marja Steenman
Journal:  Biophys Rev       Date:  2020-07-15

Review 7.  Targeting Wnt-Frizzled signaling in cardiovascular diseases.

Authors:  Saumya Pandey
Journal:  Mol Biol Rep       Date:  2013-09-21       Impact factor: 2.316

8.  Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling.

Authors:  Min Tang; Wuzhou Yuan; Xiongwei Fan; Ming Liu; Rolf Bodmer; Karen Ocorr; Xiushan Wu
Journal:  Circ Cardiovasc Genet       Date:  2013-09-17

9.  Age-dependent impaired neurogenic differentiation capacity of dental stem cell is associated with Wnt/β-catenin signaling.

Authors:  Xingmei Feng; Jing Xing; Guijuan Feng; Aimin Sang; Biyu Shen; Yue Xu; Jinxia Jiang; Suzhe Liu; Wei Tan; Zhifeng Gu; Liren Li
Journal:  Cell Mol Neurobiol       Date:  2013-09-17       Impact factor: 5.046

10.  FOXOs attenuate bone formation by suppressing Wnt signaling.

Authors:  Srividhya Iyer; Elena Ambrogini; Shoshana M Bartell; Li Han; Paula K Roberson; Rafael de Cabo; Robert L Jilka; Robert S Weinstein; Charles A O'Brien; Stavros C Manolagas; Maria Almeida
Journal:  J Clin Invest       Date:  2013-07-15       Impact factor: 14.808
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