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Literature DB >> 21106939

Gaseotransmitters: new frontiers for translational science.

Abstract

Translational research on endogenous gaseous mediators--nitric oxide, carbon monoxide, and hydrogen sulfide--has exploded over the past decade. Drugs that modulate either the gaseous mediators themselves or their related intracellular signaling pathways are already in use in the clinics, and still more are being tested in preclinical models and clinical trials. Discussed here are the chemical and pharmacological properties that present challenges for the translation of these potentially toxic molecules.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 21106939 PMCID： PMC3038605 DOI： 10.1126/scitranslmed.3000721

Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956

38 in total

Review 1. Cyclic GMP phosphodiesterase-5: target of sildenafil.

Authors: J D Corbin; S H Francis
Journal: J Biol Chem Date: 1999-05-14 Impact factor: 5.157

Review 2. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics.

Authors: Jon O Lundberg; Eddie Weitzberg; Mark T Gladwin
Journal: Nat Rev Drug Discov Date: 2008-02 Impact factor: 84.694

3. Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.

Authors: Faye Martin; Padmamalini Baskaran; Xiaolei Ma; Pete W Dunten; Martina Schaefer; Johannes-Peter Stasch; Annie Beuve; Focco van den Akker
Journal: J Biol Chem Date: 2010-05-12 Impact factor: 5.157

4. Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.

Authors: Johannes-Peter Stasch; Peter M Schmidt; Pavel I Nedvetsky; Tatiana Y Nedvetskaya; Arun Kumar H S; Sabine Meurer; Martin Deile; Ashraf Taye; Andreas Knorr; Harald Lapp; Helmut Müller; Yagmur Turgay; Christiane Rothkegel; Adrian Tersteegen; Barbara Kemp-Harper; Werner Müller-Esterl; Harald H H W Schmidt
Journal: J Clin Invest Date: 2006-09 Impact factor: 14.808

5. Half-life of blood carboxyhemoglobin after short-term and long-term exposure to carbon monoxide.

Authors: T Shimazu; H Ikeuchi; H Sugimoto; C W Goodwin; A D Mason; B A Pruitt
Journal: J Trauma Date: 2000-07

Review 6. CO as a cellular signaling molecule.

Authors: Hong Pyo Kim; Stefan W Ryter; Augustine M K Choi
Journal: Annu Rev Pharmacol Toxicol Date: 2006 Impact factor: 13.820

7. A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia.

Authors: Mathieu Desmard; Kelly S Davidge; Odile Bouvet; Didier Morin; Damien Roux; Roberta Foresti; Jean D Ricard; Erick Denamur; Robert K Poole; Philippe Montravers; Roberto Motterlini; Jorge Boczkowski
Journal: FASEB J Date: 2008-12-18 Impact factor: 5.191

Review 8. Naproxcinod, a new cyclooxygenase-inhibiting nitric oxide donator (CINOD).

Authors: Piet Geusens
Journal: Expert Opin Biol Ther Date: 2009-05 Impact factor: 4.388

Review 9. Peroxynitrite: biochemistry, pathophysiology and development of therapeutics.

Authors: Csaba Szabó; Harry Ischiropoulos; Rafael Radi
Journal: Nat Rev Drug Discov Date: 2007-08 Impact factor: 84.694

Review 10. Carbon monoxide in biology and medicine.

Authors: Stefan W Ryter; Leo E Otterbein
Journal: Bioessays Date: 2004-03 Impact factor: 4.345

47 in total

Review 1. Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications.

Authors: Csaba Szabo
Journal: Antioxid Redox Signal Date: 2012-01-30 Impact factor: 8.401

Review 2. Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects.

Authors: Katalin Módis; Eelke M Bos; Enrico Calzia; Harry van Goor; Ciro Coletta; Andreas Papapetropoulos; Mark R Hellmich; Peter Radermacher; Frédéric Bouillaud; Csaba Szabo
Journal: Br J Pharmacol Date: 2014-04 Impact factor: 8.739

Review 3. Lanthanide probes for bioresponsive imaging.

Authors: Marie C Heffern; Lauren M Matosziuk; Thomas J Meade
Journal: Chem Rev Date: 2013-12-13 Impact factor: 60.622

4. Fe²⁺-Mediated Activation of BK_Ca Channels by Rapid Photolysis of CORM-S1 Releasing CO and Fe².

Authors: Guido Gessner; Philipp Rühl; Matthias Westerhausen; Toshinori Hoshi; Stefan H Heinemann
Journal: ACS Chem Biol Date: 2020-07-29 Impact factor: 5.100

Review 5. Multiple Targeting Approaches on Histamine H3 Receptor Antagonists.

Authors: Mohammad A Khanfar; Anna Affini; Kiril Lutsenko; Katarina Nikolic; Stefania Butini; Holger Stark
Journal: Front Neurosci Date: 2016-05-30 Impact factor: 4.677

Review 6. The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning.

Authors: Ioanna Andreadou; Efstathios K Iliodromitis; Tienush Rassaf; Rainer Schulz; Andreas Papapetropoulos; Péter Ferdinandy
Journal: Br J Pharmacol Date: 2014-09-23 Impact factor: 8.739

7. Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function.

Authors: Kunihiro Suzuki; Gabor Olah; Katalin Modis; Ciro Coletta; Gabriella Kulp; Domokos Gerö; Petra Szoleczky; Tuanjie Chang; Zongmin Zhou; Lingyun Wu; Rui Wang; Andreas Papapetropoulos; Csaba Szabo
Journal: Proc Natl Acad Sci U S A Date: 2011-08-01 Impact factor: 11.205

Gaseotransmitters: new frontiers for translational science.

Review 1. Cyclic GMP phosphodiesterase-5: target of sildenafil.

Review 2. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics.

3. Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.

4. Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.

5. Half-life of blood carboxyhemoglobin after short-term and long-term exposure to carbon monoxide.

Review 6. CO as a cellular signaling molecule.

7. A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia.

Review 8. Naproxcinod, a new cyclooxygenase-inhibiting nitric oxide donator (CINOD).

Review 9. Peroxynitrite: biochemistry, pathophysiology and development of therapeutics.

Review 10. Carbon monoxide in biology and medicine.

Review 1. Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications.

Review 2. Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects.

Review 3. Lanthanide probes for bioresponsive imaging.

4. Fe²⁺-Mediated Activation of BK_Ca Channels by Rapid Photolysis of CORM-S1 Releasing CO and Fe².

Review 5. Multiple Targeting Approaches on Histamine H3 Receptor Antagonists.

Review 6. The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning.

7. Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function.

Review 8. The therapeutic potential of cystathionine β-synthetase/hydrogen sulfide inhibition in cancer.

Review 9. Regulation of vascular tone homeostasis by NO and H₂S: Implications in hypertension.

Review 10. Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes.

Gaseotransmitters: new frontiers for translational science.

Review 1. Cyclic GMP phosphodiesterase-5: target of sildenafil.

Review 2. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics.

3. Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.

4. Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.

5. Half-life of blood carboxyhemoglobin after short-term and long-term exposure to carbon monoxide.

Review 6. CO as a cellular signaling molecule.

7. A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia.

Review 8. Naproxcinod, a new cyclooxygenase-inhibiting nitric oxide donator (CINOD).

Review 9. Peroxynitrite: biochemistry, pathophysiology and development of therapeutics.

Review 10. Carbon monoxide in biology and medicine.

Review 1. Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications.

Review 2. Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects.

Review 3. Lanthanide probes for bioresponsive imaging.

4. Fe2+-Mediated Activation of BKCa Channels by Rapid Photolysis of CORM-S1 Releasing CO and Fe2.

Review 5. Multiple Targeting Approaches on Histamine H3 Receptor Antagonists.

Review 6. The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning.

7. Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function.

Review 8. The therapeutic potential of cystathionine β-synthetase/hydrogen sulfide inhibition in cancer.

Review 9. Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension.

Review 10. Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes.

4. Fe²⁺-Mediated Activation of BK_Ca Channels by Rapid Photolysis of CORM-S1 Releasing CO and Fe².

Review 9. Regulation of vascular tone homeostasis by NO and H₂S: Implications in hypertension.