What will it take to achieve virtual elimination of mother-to-child transmission of HIV? An assessment of current progress and future needs.

BACKGROUND: The number of HIV-positive pregnant women receiving antiretroviral drugs (ARVs) to prevent mother-to-child transmission (MTCT) of HIV has increased rapidly.
OBJECTIVE: To estimate the reduction in new child HIV infections resulting from prevention of MTCT (PMTCT) over the past decade. To project the potential impact of implementing the new WHO PMTCT guidelines between 2010 and 2015 and consider the efforts required to virtually eliminate MTCT, defined as <5% transmission of HIV from mother to child, or 90% reduction of infections among young children by 2015.
METHODS: Data from 25 countries with the largest numbers of HIV-positive pregnant women were used to create five scenarios to evaluate different PMTCT interventions. A demographic model, Spectrum, was used to estimate new child HIV infections as a measure of the impact of interventions.
RESULTS: Between 2000 and 2009 there was a 24% reduction in the estimated annual number of new child infections in the 25 countries, of which about one-third occurred in 2009 alone. If these countries implement the new WHO PMTCT recommendations between 2010 and 2015, and provide more effective ARV prophylaxis or treatment to 90% of HIV-positive pregnant women, 1 million new child infections could be averted by 2015. Reducing HIV incidence in reproductive age women, eliminating the current unmet need for family planning and limiting the duration of breastfeeding to 12&emsp14;months (with ARV prophylaxis) could avert an additional 264 000 infections, resulting in a total reduction of 79% of annual new child infections between 2009 and 2015, approaching but still missing the goal of virtual elimination of MTCT. DISCUSSION: To achieve virtual elimination of new child infections PMTCT programmes must achieve high coverage of more effective ARV interventions and safer infant feeding practices. In addition, a comprehensive approach including meeting unmet family planning needs and reducing new HIV infections among reproductive age women will be required.

Introduction

In 2001, and again in 2006, national governments and their development partners committed themselves to reducing infant and child HIV infections through prevention of mother-to-child transmission (PMTCT) by 50% by 2010.1 2 Recently, UNAIDS and partners have called for virtual elimination of MTCT of HIV.3 Virtual elimination includes an overarching goal of reducing the number of new child HIV infections by 90% between 2009 and 2015 and reducing MTCT to <5%. To prevent MTCT, the United Nations recommends a comprehensive four-pronged approach including (1) primary prevention of HIV infection among women of childbearing age; (2) preventing unintended pregnancies among women living with HIV; (3) preventing HIV transmission from women living with HIV to their infants and (4) providing appropriate treatment, care and support to mothers living with HIV and their children and families.4 Prongs 1, 2 and 3 are necessary to reach the first target of reducing new child infections while only prong 3 will affect the second target to lower the transmission rate.

In countries where breastfeeding is common, the probability of transmission from mother to child without any antiretroviral drugs (ARVs) is approximately 20–45%: approximately 15–25% transmission during pregnancy and 5–20% transmission during breastfeeding.5 In developed countries, where all four prongs are well implemented and the most effective ARVs are provided to HIV-positive pregnant women with limited breastfeeding, the level of MTCT has decreased to below 2%.6–8 National measures of MTCT rates are not available in most developing countries because health systems cannot directly measure HIV infections resulting from vertical transmission in a systematic way.

In November 2009 WHO released Rapid Advice: Use of Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants and published revised full guidelines in July 2010.9–12 The new guidelines emphasise the importance of treating eligible HIV-positive pregnant women (CD4≤350) with lifelong antiretroviral therapy (ART) and recommend two equivalent options of highly effective prophylaxis to HIV-positive pregnant women who do not need ART for their own health. For the first time ARV prophylaxis to either the mother or child is also recommended during breastfeeding, in settings where breastfeeding is judged to be the safest infant feeding option. Option A starts treatment of women with zidovudine at 14 weeks of gestation or as soon as possible thereafter until delivery and the infant receives nevirapine throughout breastfeeding and until 1-week after exposure to breast milk has ended. Option B starts treatment of the mother with triple ARV prophylaxis from 14 weeks or as soon as possible thereafter and continues the maternal triple drug prophylaxis until 1-week after exposure to breast milk has ended. In 2010 WHO also released Guidelines on HIV and Infant Feeding, which recommend exclusive breastfeeding for the first 6 months of life, and continued breastfeeding and complementary foods from months 6 to 12, when either the mother or baby is receiving ARVs.12

Effective prevention of MTCT requires a comprehensive approach that combines multiple interventions. While remarkable progress has been made in providing ARV regimens to HIV-positive pregnant women and to some extent in providing appropriate treatment, care and support to women living with HIV and their children, the other two prongs—preventing new HIV infections among reproductive age women and avoiding unwanted pregnancies among HIV-positive women—have had less support and success. In addition, although PMTCT is often the starting point for HIV-positive women to learn about their HIV status and enrol in HIV care and treatment services, postpartum follow-up of mother–infant pairs is often problematic for various reasons, including the lack of capacity of maternal and child health services to provide HIV testing or follow-up to HIV-exposed children.13 14

Here we describe the estimated reduction in new child HIV infections that has been achieved by providing PMTCT interventions in the 25 countries with the largest numbers of HIV-positive pregnant women. We project the potential number of child HIV infections that would be averted if 90% of HIV-positive pregnant women were provided with ARVs according to the new WHO guidelines, HIV incidence was reduced by 50% in reproductive age women and unwanted pregnancies were eliminated (by meeting all unmet family planning needs). In addition, while the new PMTCT ARV guidelines include prophylaxis during breastfeeding, we consider the impact of prolonged breastfeeding by estimating the number of new child infections that would be averted if the duration of breastfeeding while receiving prophylaxis were limited to 12 months. Although breastfeeding in many settings is safer than replacement feeding, it is important to recognise the impact of breastfeeding on HIV transmission.

Methods

Countries included in analysis

The 25 countries with the largest number of HIV-positive pregnant women were chosen for this analysis based on their 2009 estimates reported in the 2010 Towards Universal Access report.15 These countries represent 91% of HIV-positive pregnant women in lower- and middle-income countries. The 25 countries are listed in table 1.

Table 1

Incidence, unmet need for family planning, and antiretroviral drug (ARV) coverage for top 25 countries

	HIV incidence			Unmet need for contraception			ARV prophylaxis and treatment
Top 25 countries	Estimated number of HIV positive women delivering in 2009	Projected HIV incidence in 2010*	Target HIV incidence in 2015 (50% reduction of 2010 incidence)	Projected % of women in union using contraception in 2010	% of women in union reporting unmet need for family planning	Target % of women in union using contraception in 2015 (meeting unmet need)	Estimated ARV coverage % (any regimen) in 2009	Target % of women receiving 2010 WHO recommended interventions in 2015	ANC coverage-% who had at least one visit, most recent survey	ANC coverage-% who had at least four visits, most recent survey	Median duration of BF among general population (months)
Nigeria	210 000	0.39	0.19	20	20	41	22	90	58	45	19
South Africa	210 000	1.68	0.84	62	14	76	88	90	92	56	16
Mozambique	97 000	1.36	0.68	26	18	44	70	90	89	53	23
Uganda	88 000	0.75	0.38	27	41	67	53	90	94	47	22
Tanzania	84 000	0.45	0.22	34	22	56	70	90	76	62	22
Kenya	81 000	0.62	0.31	41	25	65	73	90	92	52	22
zambia	68 000	1.50	0.75	35	27	61	69	90	94	60	22
Malawi	59 000	1.05	0.53	37	28	65	58	90	92	57	24
Zimbabwe	50 000	0.86	0.43	61	13	74	56	90	94	71	19
DR Congo	36 000	0.15	0.08	27	24	52	6	90	85	47	22
Cameroon	34 000	0.59	0.29	35	20	55	27	90	82	60	18
India	40 000	0.02	0.01	60	13	73	34	90	74	37	31
Ethiopia	30 000	0.04	0.02	22	34	56	23	90	28	12	28
Cote d'lvoire	20 000	0.14	0.07	31	28	58	54	90	85	45	21
Angola†	16 000	0.21	0.11	6	NA	NA	19	90	80	32	22
Chad	16 000	0.24	0.12	11	21	32	6	90	39	18	22
Burundi	14 000	0.25	0.12	19	29	49	12	90	92	NA	24
Lesotho	14 000	2.59	0.29	45	31	76	64	90	90	70	22
Ghana	13 000	0.16	0.08	31	35	67	27	90	90	78	23
Botswana‡	13 000	2.10	1.05	63	27	90	95	95	97	NA	18
Sudan	14 000	0.10	0.05	44	26	70	2	90	64	NA	19
Rwanda	11 000	0.21	0.10	23	38	61	65	90	96	24	34
Swaziland‡	9300	2.69	1.34	54	24	78	88	95	85	79	17
Namibia‡	7700	0.46	0.23	57	7	63	88	95	95	70	17
Burkina Faso	6500	0.09	0.04	19	29	48	32	90	85	18	26

Projected using Estimation and Projection Package 2010.

Due to a lack of data on unmet need for family planning in Angola, the reduction in new child infections due to family planning in Angola was not incorporated.

The 2015 target for ARV coverage in Botswana, Namibia, South Africa and Swaziland was set to 95% since those countries had coverage values close to 90% in 2009.

Sources: Estimated number of HIV positive women delivering and estimated ARV coverage: WHO Universal Access report 2010, Unmet need for Family planning and ANC coverage: MDG indicator website http://unstats.un.org/unsd/mdg/Data.aspx, Median duration of breastfeeding: DHS surveys.

NA, Not available.

Model

In 2009 UNAIDS, WHO and partners conducted a series of training sessions to assist country teams to develop models to estimate and project their HIV epidemics using the Estimation and Projection Package (EPP)16 and Spectrum17 software package. Country teams refined and improved the projections and incorporated the latest available data. The country files used for this analysis were submitted to UNAIDS by countries’ teams in June 2010 and include data that were available at the end of 2009. Detailed descriptions of the methodologies for the models are described elsewhere 16 17 while a brief description is provided below.

Using HIV surveillance data from antenatal clinics and nationally representative household surveys, EPP fits epidemic curves for various geographical subregions using a maximum-likelihood approach. Incidence was estimated from prevalence over time, while adjusting for the number of people receiving antiretroviral therapy (ART).16 Finally, the subnational curves were aggregated to create national adult incidence curves.

HIV incidence among adults over time was transferred from EPP into Spectrum. Using demographic data from the UN Population Division's World Population Prospects 2008 revision, Spectrum projects men and women by age group over time through different stages of HIV infection (or non-infection).

National programme data were entered into Spectrum and parameters were modified based on available data. Data entered into the model related to calculating new child infections included the number of pregnant women receiving ARVs by regimen (single, dual and triple prophylaxis or ART for their own health) and type and duration of infant feeding by HIV-positive women. When countries do not have data on infant feeding practices among HIV-positive women, data from the general population were used to proxy infant feeding among HIV-positive women.

Spectrum uses the HIV incidence data estimated from EPP and creates age- and sex-specific HIV prevalence values. HIV prevalence was applied to the number of women in the age group and then age-specific fertility rates, adjusted to account for the lower fertility of HIV-positive women, were used to estimate the number of births to HIV-positive women by age of the mother.18 19 See figure 1.

Figure 1

Summary of new child infections calculations. ARV, antiretroviral drug.

MTCT was then calculated in two components: transmission during pregnancy and delivery (perinatal transmission) and transmission during breastfeeding. The assumed for different ARV regimens are shown in table 2.

Table 2

Assumed perinatal HIV transmission rates for different antiretroviral drug (ARV) regimens

ARV regimen	Percentage	Reference
No ARV	20	20
Single-dose nevirapine	11	2122
Combination therapy using dual prophylaxis	4	2324
Combination therapy using triple prophylaxis ARV	2	20
Highly active antiretroviral treatment	2

HIV-exposed infants born HIV-negative (uninfected) have a monthly probability of HIV infection based on the infant feeding method and duration as well as ARV use during breastfeeding. The assumed are shown in table 3.

Table 3

Monthly HIV transmission rates during breastfeeding

Feeding method	Percentage	Reference
Replacement feeding	0
Mixed breastfeeding during months 1–6	1.5	2526
Exclusive breastfeeding during months 1–6	0.75	2527
Mixed breastfeeding 6–36 months	0.75	2527
Breastfeeding in the presence of maternal ART or effective ARV prophylaxis	0.3	28

ART, antiretroviral therapy; ARV, antiretroviral drug.

Scenarios

Spectrum was used to create five scenarios describing different situations and different interventions. The five scenarios include:

No PMTCT. No ARVs were provided to prevent MTCT at any point during the epidemic.

Base scenario. The 2009 programme was maintained through 2015—specifically the number of women and the regimen were kept constant from 2009 to 2015.

90% on WHO guidelines. In 2010 the HIV-positive pregnant women currently receiving ARVs were switched to the 2010 WHO-recommended interventions (providing ART for women in need for their own health or starting women on ARV prophylaxis at 14 weeks and continuing ARVs throughout breastfeeding). The number of women receiving ARVs or ART was increased linearly to reach 90% by 2015.

Prongs 1,2,3. In addition to the changes in scenario 3, new HIV infections among reproductive age women were reduced by 50% and unmet need for family planning was eliminated. HIV incidence and unmet need were reduced linearly between 2010 and 2015.

Prongs 1,2,3 and reduced breastfeeding. In addition to prongs 1,2,3, median duration of breastfeeding among HIV-positive women was reduced to 12 months. See table 1 for country values.

Four comparisons were made between the scenarios to describe the impact of PMTCT.

Comparison 1

The no-PMTCT scenario described the situation if ARVs had never been available to prevent MTCT in the 25 countries. Comparing this scenario with existing coverage levels (the base scenario) provided an estimate of the impact of providing ARV prophylaxis, before the new WHO guidelines in the 25 countries.

The other comparisons were projections of what could be achieved in the coming years given different intervention levels.

Comparison 2

The base scenario was compared with the scenario where 90% of HIV-positive pregnant women received the 2010 WHO guidelines by 2015. All other elements of the epidemic remained the same following the epidemic curve projected from existing surveillance data.

Comparison 3

The base scenario was compared with the scenario in which prongs 1, 2 and 3 are implemented by 2015.

Comparison 4

Again the base scenario was compared with a scenario where, between 2010 and 2015, prongs 1, 2 and 3 are implemented and the duration of breastfeeding was limited to 12 months.

Unmet need for family planning

To project unmet need for family planning (as in scenario 4), we used the family planning module available in the Spectrum computer package. This module allows the user to describe changes in contraceptive prevalence during the timeline of the projection. We linearly increased contraceptive prevalence from the projected value in 2010 (values of contraceptive prevalence are derived from household surveys and Spectrum then projects them forward in time) to the projected value plus unmet need in 2015. A measure of unmet need was available for 24 of the 25 countries in this analysis. No data on unmet need for family planning was available for Angola so the impact of increasing family planning efforts in Angola was not included in this analysis.

Unmet need for family planning is a common measure of access to family planning and is defined as the proportion of sexually active, fecund women in a union who wish to stop or postpone childbearing and are not currently using contraception. The measure can be interpreted as the increase in contraceptive prevalence rates if all women were able to fulfil their preferences. This measure was collected in household surveys of the general population. For PMTCT we were primarily interested in reducing the unintended pregnancies among HIV-positive women. The calculation of unmet need and its limitations have been described elsewhere.29 30

Table 1 presents the current levels of HIV incidence, unmet need for family planning and ARV coverage as well as the target values according to the scenarios described. Median duration of breastfeeding among all women by country and the proportion of pregnant women attending antenatal clinics is also provided to indicate the magnitude of change required to reach the targets set in the different scenarios.

The scenarios were implemented for each country individually and results were aggregated to create one estimate for the 25 countries with the largest numbers of HIV-positive pregnant women.

In this analysis we focused on new child infections as the outcome, although we recognised that many other outcomes could be quantified with other models and data. Future models should ideally estimate HIV-free child survival as the overall goal of interventions to prevent MTCT of HIV.

Results

The scenarios described above were used to estimate the number of new child infections (mother-to-child vertical HIV infections), including perinatal infections as well as postpartum infections during breastfeeding.

Comparison 1

Between 2000 and 2009 an estimated 4.18 million children were infected with HIV in the 25 countries. If no ART or ARV prophylaxis had been provided to pregnant women approximately 4.45 million would have been infected. Cumulatively 269 000 child HIV infections were prevented in the 25 countries by providing ARVs to HIV-positive pregnant women for prophylaxis or treatment. An estimated 89 000 child infections, or a third of cumulative child infections, were averted in 2009 alone (there were an estimated 347 000 new infections in the 25 countries in 2009). Comparing the estimated annual number of new child infections in 2000 with the annual number of new infections in 2009 shows a reduction of 24% among the 25 countries. See figure 2. (The slight decline in the no-PMTCT scenario in later years reflects changes in the number of HIV-positive pregnant women as incidence declined either owing to natural progression of HIV or owing to prevention efforts.)

Figure 2

New HIV infections through mother-to-child transmission (MTCT) if antiretroviral drugs (ARVs) were not available versus reported ARV coverage, 25 countries, 2000–9. PMTCT, prevention of MTCT.

Comparison 2

Projecting into the future, if current programmes were improved so that by 2015 90% of HIV-positive pregnant women were provided with ART or highly effective ARV prophylaxis during pregnancy and throughout breastfeeding as currently recommended by WHO, of the projected 2.1 million child infections between 2010 and 2015 approximately 1 041 000 new child infections would be averted (see figure 3). In the year 2015 alone, 229 000 HIV infections would be averted among children. This is a 60% reduction in the annual number of new child infections between the year 2009 and 2015: a major step forward but still well below the goal of a 90% reduction. Even after reaching 90% of women with the new WHO recommended interventions through pregnancy and breastfeeding there would still be approximately 138 000 new child infections in the year 2015 in the 25 countries. The MTCT rate in 2015 would be approximately 11% if 90% of women were reached with PMTCT services reflecting the WHO guidelines.

Figure 3

New HIV infections through mother-to-child transmission (MTCT) for different scenarios, 25 countries, 2009–15. ARV, antiretroviral drug; PMTCT, prevention of MTCT.

Comparison 3

If in addition to providing 90% of HIV-positive pregnant women with ART or more effective ARVs as recommended by WHO, new HIV infections among reproductive age women were reduced by 50% and unmet need for family planning for HIV-positive women was eliminated, the number of new HIV infections among children could be further reduced. Implementing these interventions simultaneously would avert approximately 1 174 000 (of 2.1 million) new child HIV infections between 2010 and 2015, resulting in a 73% overall reduction in new child infections between the years 2009 and 2015 (see figure 3). As previously noted, including prongs 1 and 2 would not reduce the overall transmission rate, which would remain at approximately 11%.

Comparison 4

The median duration of breastfeeding among women in these countries was 22 months. If, in addition to the above interventions, breastfeeding was limited to 12 months a total of 1 306 000 new child infections would be averted between 2010 and 2015; avoiding 264 000 additional new child infections than the scenario with the 2010 WHO recommendations alone (see figure 3). This would result in a 79% reduction in annual new child infections in the 25 countries between 2009 and 2015. An estimated 72 000 children would be infected with HIV through vertical transmission in 2015 (see figure 4). Assuming that only the women who receive ARVs (90%) are counselled about reducing breastfeeding and the remaining 10% continue breastfeeding patterns that are reflected in the general population, the transmission rate would be approximately 8%.

Figure 4

New HIV infections through mother-to-child transmission (MTCT), 25 countries, in the year 2015. ARV, antiretroviral drug; PMTCT, prevention of MTCT.

Limitations

This analysis was limited by the fact that the transmission rates in the model are based primarily on results from clinical studies which might not reflect the effectiveness of national programmes. These assumptions are being reviewed as new data become available. The model currently does not differentiate transmission rates by the CD4 level of the mother. Future versions of the model will attempt to incorporate this difference. In addition, data on the duration and methods of infant feeding are not readily available for HIV-positive women, and especially with the new recommendations of ARV prophylaxis during breastfeeding. This limits our ability to estimate HIV transmission during breastfeeding. Breastfeeding duration from the general population was the most appropriate available data to estimate duration of breastfeeding among HIV-positive women, although this is likely to be an overestimate. However, analysis from household surveys suggest little difference between the breastfeeding practices of HIV-positive women (who reported knowing their HIV status) and HIV-negative women.31 Finally, the models rely on programme data from the countries on PMTCT coverage and ART coverage. These data can be of varying quality32 The data used for this analysis underwent a global reconciliation process comparing data reported from countries through multiple reporting mechanisms.

Discussion

Between 2000, when ARV prophylaxis for MTCT was initiated in developing countries, and 2009 approximately 269 000 new child infections were averted in the 25 highest burden countries analysed here (representing approximately 91% of HIV-positive pregnant women in low- and middle-income countries). There was an estimated 24% reduction in the number of annual new child infections between 2000 and 2009 as a result of PMTCT ARV interventions. Targets are being set at global and country level to reduce new infections due to MTCT by 90% over the coming years. In 2009 there were an estimated 347 000 new child infections in the 25 countries. A 90% reduction in new child infections would require fewer than 34 700 new infections in 2015 in the 25 countries.

Our study suggests there will still be 72 000 new child infections in 2015 in the 25 highest burden countries if we rapidly scale up PMTCT interventions (reaching 90% of women with ART or highly effective ARV prophylaxis through delivery and breastfeeding as currently recommended by WHO, halving new HIV infections among reproductive age women, eliminating unmet need for contraception and reducing the duration of breastfeeding to 12 months): a reduction of 79% in annual new child infections between 2009 and 2015. Under these assumptions, the rate of MTCT would be 8%. Both projections represent significant progress and reductions in new child infections, but still fall short of the definition of virtual elimination: a 90% reduction in new child infections or <5% transmission rate.

Reaching the ambitious new targets of virtual elimination will require significant resources and commitment, especially in specific high-burden countries with major barriers. For example Ethiopia, with very low antenatal care registration will need to increase attendance at antenatal clinics from 28% to at least 90%. Lesotho, with high HIV incidence in pregnant women, will need to reduce incidence rates from 2.6% to 1.3%. Uganda will need to increase the availability of family planning so that contraceptive use will increase from 27% to 67% (see table 1). On the other hand, 20 of the 25 countries have current antenatal care coverage (at least one visit) >75% making it feasible, with substantial effort, for these countries to reach most women with PMTCT services. However, none of the 25 countries currently reach 90% of women with the recommended four antenatal care visits (table 1), suggesting additional efforts are needed.

This analysis shows the importance of moving rapidly to the new, more effective ARV interventions recommended in the 2010 WHO guidelines, but also shows some of the limitations of achieving virtual elimination, even with the new interventions. Our analysis suggests that coverage with highly effective ARV interventions will need to be >90% (probably >95%) and that prolonged breastfeeding beyond 12 months, even with ARVs, will increase the risk of new infections. To reach an approximate 80% reduction in new child infections, the duration of breastfeeding with ARVs had to be limited to 12 months. Although one recent clinical study found extremely low monthly transmission rates among breastfeeding infants, the median monthly transmission rate over 10 clinical trials with ARV interventions between 2007 and 2010 was 0.3%.28 33 Depending on the duration of breastfeeding this transmission can accumulate to significantly increase the overall transmission rate. For example, the probability of transmission during 12 months of breastfeeding is 3.6%; adding the perinatal transmission rate with 100% of women on the 2010 WHO guideline interventions results in an overall transmission rate of 5.6%.

Given our current understanding of infant feeding practices in these 25 countries, reaching the virtual elimination goal of <5% transmission rate may not be possible by providing ARVs alone. Even if 100% of HIV-positive pregnant women were provided with the 2010 WHO guideline interventions, a transmission rate of <5% would only be possible if infant feeding were safer. In Botswana, for example, the majority of HIV-positive women choose to use replacement feed and vertical transmission is estimated to be 3.7%.34 However, replacement feeding is not a simple intervention and can lead to higher infant mortality in some settings.35 More effort is needed to ensure that mothers are fully informed about the risks and benefits of breastfeeding especially over long durations, as recommended in the WHO Guidelines on HIV and Infant Feeding.12 Even when women or children are receiving ARVs to reduce transmission there is still a probability of infection for each month that the child is exposed to breast milk. As countries begin to scale up the new WHO guidelines, including safer breastfeeding practices with ARVs, new programme data are needed on the effectiveness of ARV interventions during breastfeeding and the duration of breastfeeding among HIV-positive women.

Caution is needed when interpreting the additional impact of the different interventions. The impact of the interventions depends on the order in which they are implemented. For example, if unmet need for family planning was eliminated before ARVs were provided we would estimate that family planning had a much larger impact on reducing new child infections. We could also hypothesise that by eliminating unmet need for family planning, women living with HIV would have the children they want when they want them. This also means that the pregnancies at which PMTCT ARVs are directed would be largely wanted pregnancies. Women with such pregnancies might have a higher motivation to adhere to PMTCT regimens, a crucial factor given the earlier start and longer duration of ARVs recommended by the 2010 WHO guidelines. In practice, the interventions would not be implemented individually thus we have not estimated the individual impact of interventions here.

The PMTCT interventions described here can dramatically reduce new child HIV infections. However, these interventions have many additional benefits beyond reducing new child HIV infections. By eliminating unmet need for family planning and reducing HIV incidence by 50% in the top 25 countries 50% fewer pregnant women would be HIV positive, approximately 36 million (cumulative between 2010 and 2015) unwanted births would be avoided among all women, and 1 209 000 fewer HIV-positive pregnant women would require ARV prophylaxis.

Much of the global effort for PMTCT has been focused on prong 3, provision of ARV prophylaxis. Additional efforts are needed on prong 1, primary prevention, and prong 2, meeting the unmet need for family planning among women living with HIV to reduce child infections. Meeting the current unmet need for family planning at a country level will require considerable effort. Yet countries are more likely to reach virtual elimination if they raise demand for family planning, and strengthen programmes to meet this demand. The measure of unmet need used in this analysis is based on all women and is thus likely to be an underestimate of unmet need for HIV-positive women.36 Thus the impact of meeting unmet need for family planning might be larger than predicted in this analysis. If more women are reached with testing and counselling the demand for family planning might be even greater.

Meeting global and country-specific targets for virtual elimination of MTCT of HIV will take an enormous amount of effort and resources from government, civil society and donors. The financial requirements should be carefully considered to help countries plan effective, efficient interventions to reach these goals. Clear progress has been made in the first 10 years of this global effort. With the scale-up of more effective ARV interventions, together with a comprehensive approach to reduce new infections in pregnant women and meet family planning needs, rapid progress can be made towards virtual elimination.

Progress has been made in the first 10 years of prevention of mother-to-child transmission but significant resources are required to reach virtual elimination by 2015.

Even after providing the WHO recommended antiretroviral drug prophylaxis or antiretroviral treatment to 90% of HIV-positive pregnant women, prolonged breastfeeding will results in continued new child infections.

Strengthening programmes to improve access to family planning and reduce new HIV infections will be critical to reach the virtual elimination targets.