OBJECTIVES: To assess the incidence and impact on treatment and prognosis of occult lymph node metastasis in laryngeal cancer. PATIENTS AND METHODS: A retrospective study was performed on 164 patients treated for laryngeal cancer, initially classified as N0, with cervical lymph node dissection. RESULTS: Occult metastases were found in 41 neck specimens (12.5%) from 32 patients (19.5%). Involvement per neck level was: 7% level IIa, 2.4% IIb, 4.2% III and 2.7% IV. Lymph node involvement was significantly increased in case of T3T4 tumor or invasion of the pre-epiglottic space or cartilage. Survival was significantly influenced by pN status (pN- = 12 years, vs pN+ = 9 years; P = 0.006). CONCLUSION: Level IIb or IV involvement is rare. Superselective neck dissection (IIa, III) seems to be indicated in T1T2 N0 tumor. In case of advanced tumor or pre-epiglottic space or cartilage invasion, functional neck dissection is mandatory.
OBJECTIVES: To assess the incidence and impact on treatment and prognosis of occult lymph node metastasis in laryngeal cancer. PATIENTS AND METHODS: A retrospective study was performed on 164 patients treated for laryngeal cancer, initially classified as N0, with cervical lymph node dissection. RESULTS: Occult metastases were found in 41 neck specimens (12.5%) from 32 patients (19.5%). Involvement per neck level was: 7% level IIa, 2.4% IIb, 4.2% III and 2.7% IV. Lymph node involvement was significantly increased in case of T3T4 tumor or invasion of the pre-epiglottic space or cartilage. Survival was significantly influenced by pN status (pN- = 12 years, vs pN+ = 9 years; P = 0.006). CONCLUSION: Level IIb or IV involvement is rare. Superselective neck dissection (IIa, III) seems to be indicated in T1T2 N0 tumor. In case of advanced tumor or pre-epiglottic space or cartilage invasion, functional neck dissection is mandatory.
Authors: Ismail Zohdi; Louay S El Sharkawy; Mahmoud F El Bestar; Hazem M Abdel Tawab; Mo'men Aa Hamela; Amal A Hareedy Journal: Clin Med Insights Ear Nose Throat Date: 2015-02-09
Authors: M C Ketterer; L A Lemus Moraga; U Beitinger; J Pfeiffer; A Knopf; C Becker Journal: Eur Arch Otorhinolaryngol Date: 2020-02-11 Impact factor: 2.503
Authors: Christopher C Xiao; Sarah A Imam; Shaun A Nguyen; Marc P Camilon; Andrew B Baker; Terry A Day; Eric J Lentsch Journal: World J Otorhinolaryngol Head Neck Surg Date: 2019-12-05
Authors: Giovanni Salzano; Francesco Perri; Fabio Maglitto; Giulia Togo; Gianluca Renato De Fazio; Michela Apolito; Federica Calabria; Claudia Laface; Luigi Angelo Vaira; Umberto Committeri; Mario Balia; Ettore Pavone; Corrado Aversa; Francesco Antonio Salzano; Vincenzo Abbate; Alessandro Ottaiano; Marco Cascella; Mariachiara Santorsola; Roberta Fusco; Luigi Califano; Franco Ionna Journal: J Pers Med Date: 2021-11-25