| Literature DB >> 21106456 |
Sriram Tyagarajan1, Prasun K Chakravarty, Bishan Zhou, Brett Taylor, Ronsar Eid, Michael H Fisher, William H Parsons, Mathew J Wyvratt, Kathryn A Lyons, Tracy Klatt, Xiaohua Li, Sanjeev Kumar, Brande Williams, John Felix, Birgit T Priest, Richard M Brochu, Vivien Warren, McHardy Smith, Maria Garcia, Gregory J Kaczorowski, William J Martin, Catherine Abbadie, Erin McGowan, Nina Jochnowitz, Ann Weber, Joseph L Duffy.
Abstract
A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.Entities:
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Year: 2010 PMID： 21106456 DOI： 10.1016/j.bmcl.2010.10.017
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823