| Literature DB >> 21106451 |
Vinay M Girijavallabhan1, Lei Chen, Chaoyang Dai, Robert J Feltz, Luke Firmansjah, Dansu Li, Seong Heon Kim, Joseph A Kozlowski, Brian J Lavey, Aneta Kosinski, John J Piwinski, Janeta Popovici-Muller, Razia Rizvi, Kristin E Rosner, Banderpalle B Shankar, Neng-Yang Shih, M Arshad Siddiqui, Ling Tong, Michael K C Wong, De-yi Yang, Liping Yang, Wensheng Yu, Guowei Zhou, Zhuyan Guo, Peter Orth, Vincent Madison, Hong Bian, Daniel Lundell, Xiaoda Niu, Himanshu Shah, Jing Sun, Shelby Umland.
Abstract
Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency (K(i)) as well as excellent activity in human whole blood. These studies led to the discovery of highly potent TACE inhibitors with good DMPK profiles. Published by Elsevier Ltd.Entities:
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Year: 2010 PMID： 21106451 DOI： 10.1016/j.bmcl.2010.10.081
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823