| Literature DB >> 2110636 |
T R Tölle1, J M Castro-Lopes, A Coimbra, W Zieglgänsberger.
Abstract
The expression of the proto-oncogene c-fos in neurons of the spinal cord dorsal horn of the rat following noxious thermal stimulation was compared in morphine- and ketamine-treated animals. Intravenous injection of morphine reduced the number of c-fos-positive neurons by up to 85% in laminae III-VI and X. This effect was dose dependent and naloxone reversible. The non-competitive N-methyl-D-aspartate (NMDA) antagonist ketamine had no effect. The present data show that morphine suppresses the induction of c-fos. A block of Ca2+ influx through voltage- and ligand (NMDA)-gated channels does not influence c-fos protein synthesis in the dorsal horn of the spinal cord in vivo.Entities:
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Year: 1990 PMID： 2110636 DOI： 10.1016/0304-3940(90)90342-7
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046