OBJECTIVE: To investigate the prevalence of positive serologic findings for celiac disease in Indian women with poor reproductive performance. DESIGN: Cross-sectional except that the women with intrauterine growth restriction were followed prospectively until delivery. SETTING: Department of Obstetrics and Gynecology of a tertiary teaching hospital, New Delhi. PATIENT(S): Eight hundred ninety-three women (104 women with idiopathic recurrent abortion, 104 women with unexplained stillbirth, 230 cases of unexplained infertility, 150 pregnant women with idiopathic intrauterine growth restriction, 305 control cases). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The presence of antigliadin IgA and IgG, anti-tissue transglutaminase IgA by ELISA, and IgA antiendomysium antibody by indirect immunofluorescence microscopy. RESULT(S): The seroprevalence of transglutaminase IgA was 6.70% in the group with recurrent abortion, 5.70% in the group with stillbirth, 5.65% in the group with infertility, 9.33% in the group with intrauterine growth restriction, and 1.30% in the control group. Rates of previous preterm births, low-birth-weight infants, and cesarean section were higher in seropositive women compared with seronegative subjects. CONCLUSION(S): Women having poor reproductive performance had subclinical celiac disease. The serology for celiac disease can be considered in idiopathic cases.
OBJECTIVE: To investigate the prevalence of positive serologic findings for celiac disease in Indian women with poor reproductive performance. DESIGN: Cross-sectional except that the women with intrauterine growth restriction were followed prospectively until delivery. SETTING: Department of Obstetrics and Gynecology of a tertiary teaching hospital, New Delhi. PATIENT(S): Eight hundred ninety-three women (104 women with idiopathic recurrent abortion, 104 women with unexplained stillbirth, 230 cases of unexplained infertility, 150 pregnant women with idiopathic intrauterine growth restriction, 305 control cases). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The presence of antigliadin IgA and IgG, anti-tissue transglutaminase IgA by ELISA, and IgA antiendomysium antibody by indirect immunofluorescence microscopy. RESULT(S): The seroprevalence of transglutaminase IgA was 6.70% in the group with recurrent abortion, 5.70% in the group with stillbirth, 5.65% in the group with infertility, 9.33% in the group with intrauterine growth restriction, and 1.30% in the control group. Rates of previous preterm births, low-birth-weight infants, and cesarean section were higher in seropositive women compared with seronegative subjects. CONCLUSION(S): Women having poor reproductive performance had subclinical celiac disease. The serology for celiac disease can be considered in idiopathic cases.
Authors: B Toth; W Würfel; M K Bohlmann; G Gillessen-Kaesbach; F Nawroth; N Rogenhofer; C Tempfer; T Wischmann; M von Wolff Journal: Geburtshilfe Frauenheilkd Date: 2015-11 Impact factor: 2.915
Authors: Louise B Grode; Inge E Agerholm; Peter Humaidan; Tina Parkner; Bodil H Bech; Cecilia H Ramlau-Hansen; Thomas M Jensen Journal: United European Gastroenterol J Date: 2018-08-24 Impact factor: 4.623
Authors: Stephanie M Moleski; Christina C Lindenmeyer; J Jon Veloski; Robin S Miller; Cynthia L Miller; David Kastenberg; Anthony J DiMarino Journal: Ann Gastroenterol Date: 2015 Apr-Jun