BACKGROUND: Low-grade extraskeletal osteosarcomas (ESOS) are extremely rare. CASE PRESENTATION: We present the first case of low-grade ESOS of the chest wall, which occurred in a 30-year-old man. Because of initial misdiagnosis and patient's refusal of surgery, the diagnosis was done after a 4-year history of a slowly growing mass in soft tissues, leading to a huge (30-cm diameter) calcified mass locally extended over the left chest wall. Final diagnosis was helped by molecular analysis of MDM2 and CDK4 oncogenes. Unfortunately, at this time, no surgical treatment was possible due to loco-regional extension, and despite chemotherapy, the patient died one year after diagnosis, five years after the first symptoms. CONCLUSION: We describe the clinical, radiological and bio-pathological features of this unique case, and review the literature concerning low-grade ESOS. Our case highlights the diagnostic difficulties for such very rare tumours and the interest of molecular analysis in ambiguous cases.
BACKGROUND: Low-grade extraskeletal osteosarcomas (ESOS) are extremely rare. CASE PRESENTATION: We present the first case of low-grade ESOS of the chest wall, which occurred in a 30-year-old man. Because of initial misdiagnosis and patient's refusal of surgery, the diagnosis was done after a 4-year history of a slowly growing mass in soft tissues, leading to a huge (30-cm diameter) calcified mass locally extended over the left chest wall. Final diagnosis was helped by molecular analysis of MDM2 and CDK4 oncogenes. Unfortunately, at this time, no surgical treatment was possible due to loco-regional extension, and despite chemotherapy, the patient died one year after diagnosis, five years after the first symptoms. CONCLUSION: We describe the clinical, radiological and bio-pathological features of this unique case, and review the literature concerning low-grade ESOS. Our case highlights the diagnostic difficulties for such very rare tumours and the interest of molecular analysis in ambiguous cases.
Authors: David Gisselsson; Eva Pålsson; Mattias Höglund; Henryk Domanski; Fredrik Mertens; Nikos Pandis; Raf Sciot; Paola Dal Cin; Julia A Bridge; Nils Mandahl Journal: Genes Chromosomes Cancer Date: 2002-02 Impact factor: 5.006
Authors: G Gamberi; P Ragazzini; M S Benassi; C Ferrari; M R Sollazzo; L Molendini; M Merli; G Magagnoli; P Ruggieri; A Balladelli; C Orlando; P Bacchini; M Pazzagli; P Picci Journal: Clin Orthop Relat Res Date: 2000-08 Impact factor: 4.176
Authors: Zhengfu Fan; Shreyaskumar Patel; Valerae O Lewis; B Ashleigh Guadagnolo; Patrick P Lin Journal: Clin Orthop Relat Res Date: 2015-07-22 Impact factor: 4.176