PURPOSE: To determine the association between vitamin D status and the serum lipid profile in children. METHODS: The subjects of this cross-sectional study were 149 Spanish school children (8-13 years of age). The anthropometric data collected were weight and height, from which the body mass index (BMI) was calculated. Serum 25(OH)D concentrations were measured by chemiluminescent assay. Triglycerides were determined by enzyme colorimetry; total cholesterol and HDL-cholesterol were determined by the cholesterol esterase method. The LDL-cholesterol concentrations were determined mathematically. RESULTS: Compared to children with serum 25(OH)D concentrations in the fourth quartile, those in the first had higher triglyceride (86.0 ± 35.7 vs. 64.1 ± 26.7 mg/dL; p < 0.05). After adjusting for age, sex, BMI, and physical activity, the serum 25(OH)D level was found to be inversely proportional to the triglyceride (r = -0.857; p = 0.010). While age, sex, BMI, and physical activity explained 12% of the variance of the HDL-cholesterol figures, the inclusion of serum 25(OH)D allowed 23% of the variance to be explained. CONCLUSION: A low serum vitamin D levels in children is associated with high triglyceride levels.
PURPOSE: To determine the association between vitamin D status and the serum lipid profile in children. METHODS: The subjects of this cross-sectional study were 149 Spanish school children (8-13 years of age). The anthropometric data collected were weight and height, from which the body mass index (BMI) was calculated. Serum 25(OH)D concentrations were measured by chemiluminescent assay. Triglycerides were determined by enzyme colorimetry; total cholesterol and HDL-cholesterol were determined by the cholesterol esterase method. The LDL-cholesterol concentrations were determined mathematically. RESULTS: Compared to children with serum 25(OH)D concentrations in the fourth quartile, those in the first had higher triglyceride (86.0 ± 35.7 vs. 64.1 ± 26.7 mg/dL; p < 0.05). After adjusting for age, sex, BMI, and physical activity, the serum 25(OH)D level was found to be inversely proportional to the triglyceride (r = -0.857; p = 0.010). While age, sex, BMI, and physical activity explained 12% of the variance of the HDL-cholesterol figures, the inclusion of serum 25(OH)D allowed 23% of the variance to be explained. CONCLUSION: A low serum vitamin D levels in children is associated with high triglyceride levels.
Authors: Armin Zittermann; Sabine Frisch; Heiner K Berthold; Christian Götting; Joachim Kuhn; Knut Kleesiek; Peter Stehle; Heinrich Koertke; Reiner Koerfer Journal: Am J Clin Nutr Date: 2009-03-25 Impact factor: 7.045
Authors: Sara A Chacko; Yiqing Song; JoAnn E Manson; Linda Van Horn; Charles Eaton; Lisa W Martin; Anne McTiernan; J David Curb; Judith Wylie-Rosett; Lawrence S Phillips; Raymond A Plodkowski; Simin Liu Journal: Am J Clin Nutr Date: 2011-05-25 Impact factor: 7.045
Authors: Maria I Van Rompay; Nicola M McKeown; Elizabeth Goodman; Misha Eliasziw; Virginia R Chomitz; Catherine M Gordon; Christina D Economos; Jennifer M Sacheck Journal: J Nutr Date: 2015-09-02 Impact factor: 4.798
Authors: Rachel Lieberman; R Paul Wadwa; Nhung Nguyen; Franziska K Bishop; Christina Reinick; Janet K Snell-Bergeon; David M Maahs Journal: PLoS One Date: 2013-10-29 Impact factor: 3.240