Literature DB >> 21103520

A two step route to indoles from haloarenes--a versatile variation on the Fischer indole synthesis.

Martyn Inman1, Christopher J Moody.   

Abstract

In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen-magnesium exchange, quenching with di-tert-butyl azodicarboxylate, followed by reaction with ketones under acidic conditions.

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Year:  2010        PMID: 21103520     DOI: 10.1039/c0cc04306k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  3 in total

1.  Au-catalyzed synthesis of 2-alkylindoles from N-arylhydroxylamines and terminal alkynes.

Authors:  Yanzhao Wang; Longwu Ye; Liming Zhang
Journal:  Chem Commun (Camb)       Date:  2011-06-03       Impact factor: 6.222

2.  Combining Zn Ion Catalysis with Homogeneous Gold Catalysis: An Efficient Annulation Approach to N-Protected Indoles.

Authors:  Yanzhao Wang; Lianzhu Liu; Liming Zhang
Journal:  Chem Sci       Date:  2013-02-01       Impact factor: 9.825

3.  Marine Sponge/H3PO4: As a Naturally Occurring Chiral Catalyst for Solvent-free Fischer-Indole Synthesis.

Authors:  Mohammad Reza Shushizadeh; Azar Mostoufi; Rashid Badri; Somaye Azizyan
Journal:  Jundishapur J Nat Pharm Prod       Date:  2013-11-01
  3 in total

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