Literature DB >> 2110244

Expression and role of p75 interleukin 2 receptor on human monocytes.

I Espinoza-Delgado1, J R Ortaldo, R Winkler-Pickett, K Sugamura, L Varesio, D L Longo.   

Abstract

We investigated the expression of IL-2R subunits in human monocytes using the TU27 mAb, which recognizes the p75 chain, and anti-Tac mAb, which recognizes the p55 moiety of the IL-2R. We found that p75 but not p55 is constitutively expressed in more than 90% of fresh human monocytes. Antibody to p75, but not to p55, inhibited the activation of monocytes to a cytotoxic stage induced by IL-2 but did not block IFN-gamma-induced cytotoxicity. Our data demonstrate that the p75 chain is expressed on human monocytes and is involved in the activation of monocytes by IL-2.

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Year:  1990        PMID： 2110244      PMCID： PMC2187901          DOI： 10.1084/jem.171.5.1821

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  10 in total

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