INTRODUCTION: Photic driving is believed to be increased in migraineurs and has been interpreted as a sign of cortical hyperexcitability. However, most previous studies have included patients in various phases of the migraine cycle. The results are, therefore, difficult to interpret as neurophysiological abnormalities tend to accumulate close to the attack in migraineurs. SUBJECTS AND METHODS: We recorded steady state visual evoked EEG-responses (SSVEPs) for 6, 12, 18 and 24 Hz flash stimuli from 33 migraineurs without aura, eight migraineurs with aura and 32 healthy controls. Interictal recordings were compared pair-wise with recordings before, during and after attack, as well as with EEGs from healthy controls. Driving power was also correlated with sensory hypersensitivity and severity of migraine. RESULTS: Between attacks, driving responses to 18 Hz and 24 Hz were attenuated in migraineurs without aura. Driving power of 12 Hz increased before the attack. Attack trigger sensitivity, photophobia, pain intensity and a family history of migraine were related to decreased and/or symmetric photic driving. CONCLUSIONS: Earlier results may have overestimated the driving response in migraine due to inclusion of recordings during the preictal interval and/or habituation among controls. Abnormal photic driving may be related to the pathophysiology of clinical sensory hypersensitivity.
INTRODUCTION: Photic driving is believed to be increased in migraineurs and has been interpreted as a sign of cortical hyperexcitability. However, most previous studies have included patients in various phases of the migraine cycle. The results are, therefore, difficult to interpret as neurophysiological abnormalities tend to accumulate close to the attack in migraineurs. SUBJECTS AND METHODS: We recorded steady state visual evoked EEG-responses (SSVEPs) for 6, 12, 18 and 24 Hz flash stimuli from 33 migraineurs without aura, eight migraineurs with aura and 32 healthy controls. Interictal recordings were compared pair-wise with recordings before, during and after attack, as well as with EEGs from healthy controls. Driving power was also correlated with sensory hypersensitivity and severity of migraine. RESULTS: Between attacks, driving responses to 18 Hz and 24 Hz were attenuated in migraineurs without aura. Driving power of 12 Hz increased before the attack. Attack trigger sensitivity, photophobia, pain intensity and a family history of migraine were related to decreased and/or symmetric photic driving. CONCLUSIONS: Earlier results may have overestimated the driving response in migraine due to inclusion of recordings during the preictal interval and/or habituation among controls. Abnormal photic driving may be related to the pathophysiology of clinical sensory hypersensitivity.
Authors: Eulália Silva dos Santos Pinheiro; Fernanda Costa de Queirós; Pedro Montoya; Cleber Luz Santos; Marion Alves do Nascimento; Clara Hikari Ito; Manuela Silva; David Barros Nunes Santos; Silvia Benevides; José Garcia Vivas Miranda; Katia Nunes Sá; Abrahão Fontes Baptista Journal: PLoS One Date: 2016-02-25 Impact factor: 3.240
Authors: Sophie L Wilcox; Rosanna Veggeberg; Jordan Lemme; Duncan J Hodkinson; Steven Scrivani; Rami Burstein; Lino Becerra; David Borsook Journal: Front Hum Neurosci Date: 2016-07-26 Impact factor: 3.169
Authors: Matthijs Jl Perenboom; Mark van de Ruit; Ronald Zielman; Arn Mjm van den Maagdenberg; Michel D Ferrari; Johannes A Carpay; Else A Tolner Journal: Cephalalgia Date: 2020-03-18 Impact factor: 6.292