Literature DB >> 2109713

Effects of ganglioside (Cronassial) treatment on MHC Ia antigen expression and allograft survival of pancreatic islets in diabetic rats.

R G Bretzel1, B K Flesch, J Willig, M Woehrle, K Federlin.   

Abstract

Streptozotocin-diabetic BdII rats were treated daily with 20 mg/kg body weight gangliosides for ten days beginning two days before transplantation. This treatment did not prolong allograft survival of untreated Lewis islets. Culture treatment of isolated Lewis islets with gangliosides (100 micrograms/ml in RPMI 1640) for one day resulted in a significant reduction of MHC Ia antigen positive cells but not of class I antigens within the islets. Transplantation of the ganglioside pretreated islets into non-immunosuppressed BdII recipients prolonged allograft survival to 12 days only in one of five animals.

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Year:  1990        PMID： 2109713     DOI： 10.1007/bf00401049

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  5 in total

1.  An improved method for isolation of mouse pancreatic islets.

Authors:  M Gotoh; T Maki; T Kiyoizumi; S Satomi; A P Monaco
Journal:  Transplantation       Date:  1985-10       Impact factor: 4.939

2.  Gangliosides induce selective modulation of CD4 from helper T lymphocytes.

Authors:  H Offner; T Thieme; A A Vandenbark
Journal:  J Immunol       Date:  1987-11-15       Impact factor: 5.422

3.  Regulation of lymphocyte responses by human gangliosides. I. Characteristics of inhibitory effects and the induction of impaired activation.

Authors:  R L Whisler; A J Yates
Journal:  J Immunol       Date:  1980-11       Impact factor: 5.422

4.  Inhibition of interleukin-2-dependent cytotoxic T-lymphocyte growth by gangliosides.

Authors:  W D Merritt; J M Bailey; D H Pluznik
Journal:  Cell Immunol       Date:  1984-11       Impact factor: 4.868

5.  Gangliosides in vivo reduce diabetes incidence in non-obese diabetic mice.

Authors:  S Wilberz; L Herberg; A E Renold
Journal:  Diabetologia       Date:  1988-11       Impact factor: 10.122
  5 in total
  1 in total

1.  Pancreatic duct inflammatory infiltration in the nonobese diabetic (NOD) mouse.

Authors:  G Papaccio; G C Baccari; C Strate; T Linn
Journal:  J Anat       Date:  1994-12       Impact factor: 2.610
  1 in total

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