Literature DB >> 2109700

Possible protein binding displacement interaction between glibenclamide and metolazone.

S George1, A McBurney, A Cole.   

Abstract

The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significant increase in the free fraction of glibenclamide in patients receiving both drugs.

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Year:  1990        PMID： 2109700     DOI： 10.1007/bf00314813

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  8 in total

1.  Pharmacokinetic disposition of 14C-glyburide in patients with varying renal function.

Authors:  J G Pearson; E J Antal; C L Raehl; H K Gorsch; W A Craig; K S Albert; P G Welling
Journal:  Clin Pharmacol Ther       Date:  1986-03       Impact factor: 6.875

2.  Pharmacokinetics of metolazone in normal subjects and in patients with cardiac or renal failure.

Authors:  W J Tilstone; H Dargie; E N Dargie; H G Morgan; A C Kennedy
Journal:  Clin Pharmacol Ther       Date:  1974-08       Impact factor: 6.875

Review 3.  The relationship between the pharmacokinetics and pharmacodynamic effects of oral hypoglycaemic drugs.

Authors:  R E Ferner; S Chaplin
Journal:  Clin Pharmacokinet       Date:  1987-06       Impact factor: 6.447

4.  Displacement of tolbutamide, glibencalmide and chlorpropamide from serum albumin by anionic drugs.

Authors:  K F Brown; M J Crooks
Journal:  Biochem Pharmacol       Date:  1976-05-15       Impact factor: 5.858

5.  The binding of sulphonylureas to serum albumin.

Authors:  M J Crooks; K F Brown
Journal:  J Pharm Pharmacol       Date:  1974-05       Impact factor: 3.765

6.  Glibenclamide-associated hypoglycaemia: a report on 57 cases.

Authors:  K Asplund; B E Wiholm; F Lithner
Journal:  Diabetologia       Date:  1983-06       Impact factor: 10.122

Review 7.  Sulphonylurea antidiabetic drugs. An update of their clinical pharmacology and rational therapeutic use.

Authors:  A Melander; P O Bitzén; O Faber; L Groop
Journal:  Drugs       Date:  1989-01       Impact factor: 9.546

Review 8.  Pharmacokinetic-pharmacodynamic relationships of oral hypoglycaemic agents. An update.

Authors:  P Marchetti; R Navalesi
Journal:  Clin Pharmacokinet       Date:  1989-02       Impact factor: 6.447
  8 in total
  2 in total

1.  Acute inhibition of ATP-sensitive K+ channels impairs skeletal muscle vascular control in rats during treadmill exercise.

Authors:  Clark T Holdsworth; Steven W Copp; Scott K Ferguson; Gabrielle E Sims; David C Poole; Timothy I Musch
Journal:  Am J Physiol Heart Circ Physiol       Date:  2015-03-27       Impact factor: 4.733

2.  ATP-sensitive K+ channel inhibition in rats decreases kidney and skeletal muscle blood flow without increasing sympathetic nerve discharge.

Authors:  Trenton D Colburn; Clark T Holdsworth; Jesse C Craig; Daniel M Hirai; Shawnee Montgomery; David C Poole; Timothy I Musch; Michael J Kenney
Journal:  Respir Physiol Neurobiol       Date:  2020-04-21       Impact factor: 1.931
  2 in total

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