| Literature DB >> 21094606 |
Christopher A Luckhurst1, Linda A Stein, Mark Furber, Nicola Webb, Marianne J Ratcliffe, Gary Allenby, Sara Botterell, Wendy Tomlinson, Barrie Martin, Andrew Walding.
Abstract
Small molecule isoindoline and tetrahydroisoquinoline derivatives have been identified as selective agonists of human peroxisome proliferator-activated receptor δ (PPARδ. Compound 18 demonstrated efficacy in a biomarker for increased fatty acid oxidation, with upregulation of pyruvate dehydrogenase kinase, isozyme 4 (PDK4) in human primary myotubes.Entities:
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Year: 2010 PMID： 21094606 DOI： 10.1016/j.bmcl.2010.10.117
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823