Literature DB >> 21094565

Discovery of highly potent agents against influenza A virus.

Xin Zhao1, Chufang Li, Shaogao Zeng, Wenhui Hu.   

Abstract

We previously reported several new M2 inhibitors as active as amantadine against influenza A virus and validated by three types of in vitro assays. Herein, we further modified one of the most potent hits in a viral inhibition assay and conducted structure-activity relationship studies on this scaffold. As a result, compound 8e was identified to be the most potent inhibitor against wild-type influenza A virus, being nearly 240-fold more active than amantadine.
Copyright © 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 21094565     DOI： 10.1016/j.ejmech.2010.10.010

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  12 in total

1.  Detection of proton movement directly across viral membranes to identify novel influenza virus M2 inhibitors.

Authors:  Chidananda Sulli; Soma S R Banik; Justin Schilling; Allan Moser; Xiaoxiao Xiang; Riley Payne; Antony Wanless; Sharon H Willis; Cheryl Paes; Joseph B Rucker; Benjamin J Doranz
Journal:  J Virol       Date:  2013-07-24       Impact factor: 5.103

2.  Discovery of Highly Potent Pinanamine-Based Inhibitors against Amantadine- and Oseltamivir-Resistant Influenza A Viruses.

Authors:  Xin Zhao; Runfeng Li; Yang Zhou; Mengjie Xiao; Chunlong Ma; Zhongjin Yang; Shaogao Zeng; Qiuling Du; Chunguang Yang; Haiming Jiang; Yanmei Hu; Kefeng Wang; Chris Ka Pun Mok; Ping Sun; Jianghong Dong; Wei Cui; Jun Wang; Yaoquan Tu; Zifeng Yang; Wenhui Hu
Journal:  J Med Chem       Date:  2018-06-11       Impact factor: 7.446

3.  Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus.

Authors:  Jizhou Wang; Chunlong Ma; Jun Wang; Hyunil Jo; Belgin Canturk; Giacomo Fiorin; Lawrence H Pinto; Robert A Lamb; Michael L Klein; William F DeGrado
Journal:  J Med Chem       Date:  2013-03-27       Impact factor: 7.446

Review 4.  Recent progress in structure-based anti-influenza drug design.

Authors:  Juan Du; Timothy A Cross; Huan-Xiang Zhou
Journal:  Drug Discov Today       Date:  2012-06-13       Impact factor: 7.851

Review 5.  Nitrogen-Containing Heterocyclic Compounds Obtained from Monoterpenes or Their Derivatives: Synthesis and Properties.

Authors:  Vladimir V Chernyshov; Irina I Popadyuk; Olga I Yarovaya; Nariman F Salakhutdinov
Journal:  Top Curr Chem (Cham)       Date:  2022-08-11

6.  Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.

Authors:  Fang Li; Chunlong Ma; William F DeGrado; Jun Wang
Journal:  J Med Chem       Date:  2016-01-29       Impact factor: 7.446

7.  Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus.

Authors:  Jun Wang; Yibing Wu; Chunlong Ma; Giacomo Fiorin; Jizhou Wang; Lawrence H Pinto; Robert A Lamb; Michael L Klein; William F Degrado
Journal:  Proc Natl Acad Sci U S A       Date:  2013-01-09       Impact factor: 11.205

8.  Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay.

Authors:  Aruna D Balgi; Jun Wang; Daphne Y H Cheng; Chunlong Ma; Tom A Pfeifer; Yoko Shimizu; Hilary J Anderson; Lawrence H Pinto; Robert A Lamb; William F DeGrado; Michel Roberge
Journal:  PLoS One       Date:  2013-02-01       Impact factor: 3.240

Review 9.  New small-molecule drug design strategies for fighting resistant influenza A.

Authors:  Zuyuan Shen; Kaiyan Lou; Wei Wang
Journal:  Acta Pharm Sin B       Date:  2015-09-06       Impact factor: 11.413

10.  Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus.

Authors:  A S Sokolova; O I Yarovaya; M D Semenova; A A Shtro; I R Orshanskaya; V V Zarubaev; N F Salakhutdinov
Journal:  Medchemcomm       Date:  2017-03-03       Impact factor: 3.597
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