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Literature DB >> 21093720

The biology of aging and frailty.

Abstract

In developing and validating the concept of frailty as a geriatric syndrome, it has been necessary to distinguish the clinical expression of frailty from normal age-related changes and other age-related disease pathologies. A framework for excluding potentially confounding disease and a working clinical tool to diagnose frailty have been provided. The associations between frailty and other pathophysiologies has also been shown. However, investigating the underlying biologic basis for the geriatric syndrome of frailty by studying basic homeostatic pathways and mechanisms has not proceeded at the same rate. The following article provides an overview of the homeostatic pathways emphasized in research on aging and explains how this science may help to stimulate frailty research.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2011 PMID： 21093720 PMCID： PMC3052959 DOI： 10.1016/j.cger.2010.08.006

Source DB: PubMed Journal: Clin Geriatr Med ISSN： 0749-0690 Impact factor: 3.076

88 in total

Review 1. Role of oxidative stress in telomere length regulation and replicative senescence.

Authors: T von Zglinicki
Journal: Ann N Y Acad Sci Date: 2000-06 Impact factor: 5.691

2. Protein degradation during aging: the lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systems.

Authors: Niki Chondrogianni; Emmanouil G Fragoulis; Efstathios S Gonos
Journal: Biogerontology Date: 2002 Impact factor: 4.277

Review 3. Molecular mechanisms of apoptosis in the cells of the immune system in human aging.

Authors: Sudhir Gupta
Journal: Immunol Rev Date: 2005-06 Impact factor: 12.988

Review 4. Impaired apoptosis and immune senescence - cause or effect?

Authors: Hui-Chen Hsu; Donald K Scott; John D Mountz
Journal: Immunol Rev Date: 2005-06 Impact factor: 12.988

5. Frailty in older adults: evidence for a phenotype.

Authors: L P Fried; C M Tangen; J Walston; A B Newman; C Hirsch; J Gottdiener; T Seeman; R Tracy; W J Kop; G Burke; M A McBurnie
Journal: J Gerontol A Biol Sci Med Sci Date: 2001-03 Impact factor: 6.053

6. p65/RelA modulates BECN1 transcription and autophagy.

Authors: Tamara Copetti; Cosetta Bertoli; Emiliano Dalla; Francesca Demarchi; Claudio Schneider
Journal: Mol Cell Biol Date: 2009-03-16 Impact factor: 4.272

Review 7. Cellular senescence and organismal aging.

Authors: Jessie C Jeyapalan; John M Sedivy
Journal: Mech Ageing Dev Date: 2008-04-12 Impact factor: 5.432

8. Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty.

Authors: Tao Qu; Huanle Yang; Jeremy D Walston; Neal S Fedarko; Sean X Leng
Journal: Cytokine Date: 2009-04-01 Impact factor: 3.861

9. Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor.

Authors: Jinghui Zhao; Jeffrey J Brault; Andreas Schild; Alfred L Goldberg
Journal: Autophagy Date: 2008-01-23 Impact factor: 16.016

Review 10. The epidemiology of low-grade chronic systemic inflammation and type 2 diabetes.

Authors: Bruce B Duncan; Maria Inês Schmidt
Journal: Diabetes Technol Ther Date: 2006-02 Impact factor: 6.118

60 in total

1. Proteomic screening of glycoproteins in human plasma for frailty biomarkers.

Authors: Kinza S Shamsi; Anson Pierce; Aaron S Ashton; Dipti G Halade; Arlan Richardson; Sara E Espinoza
Journal: J Gerontol A Biol Sci Med Sci Date: 2012-01-04 Impact factor: 6.053

2. The frailty index in Europeans: association with age and mortality.

Authors: Roman Romero-Ortuno; Rose Anne Kenny
Journal: Age Ageing Date: 2012-04-19 Impact factor: 10.668

3. Higher dietary acid load is associated with a higher prevalence of frailty, particularly slowness/weakness and low physical activity, in elderly Japanese women.

Authors: Yuki Kataya; Kentaro Murakami; Satomi Kobayashi; Hitomi Suga; Satoshi Sasaki
Journal: Eur J Nutr Date: 2017-04-12 Impact factor: 5.614

The biology of aging and frailty.

Review 1. Role of oxidative stress in telomere length regulation and replicative senescence.

2. Protein degradation during aging: the lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systems.

Review 3. Molecular mechanisms of apoptosis in the cells of the immune system in human aging.

Review 4. Impaired apoptosis and immune senescence - cause or effect?

5. Frailty in older adults: evidence for a phenotype.

6. p65/RelA modulates BECN1 transcription and autophagy.

Review 7. Cellular senescence and organismal aging.

8. Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty.

9. Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor.

Review 10. The epidemiology of low-grade chronic systemic inflammation and type 2 diabetes.

1. Proteomic screening of glycoproteins in human plasma for frailty biomarkers.

2. The frailty index in Europeans: association with age and mortality.

3. Higher dietary acid load is associated with a higher prevalence of frailty, particularly slowness/weakness and low physical activity, in elderly Japanese women.

4. Malnutrition in pre-dialysis chronic kidney disease patients in a teaching hospital in Southern Nigeria.

Review 5. Frailty as a prognostic indicator in the radical cystectomy population: a review.

6. The Predictability of Frailty Associated with Musculoskeletal Deficits: A Longitudinal Study.

7. Frailty, Inflammation, and Mortality Among Persons Aging With HIV Infection and Injection Drug Use.

8. Plasma protein biomarkers of the geriatric syndrome of frailty.

Review 9. Frailty, Aging, and Cardiovascular Surgery.

10. Serum chitotriosidase, a putative marker of chronically activated macrophages, increases with normal aging.