| Literature DB >> 21093608 |
Guodong Chen1, Bethanne M Warrack, Angela K Goodenough, Hui Wei, David B Wang-Iverson, Adrienne A Tymiak.
Abstract
Mass spectrometry (MS) has become a powerful technology in the discovery and development of protein therapeutics in the biopharmaceutical industry. This review article describes recent developments and future trends in the characterization of protein therapeutics using MS. We discuss top-down MS for the characterization of protein modifications, hydrogen/deuterium exchange MS and ion mobility MS methods for higher order protein structure studies. Quantitative analysis of protein therapeutics (in vivo) by MS as an orthogonal approach to immunoassay for pharmacokinetics studies will also be illustrated.Entities:
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Year: 2010 PMID： 21093608 DOI： 10.1016/j.drudis.2010.11.003
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851