Literature DB >> 2109351

A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons.

J Oberdick1, R J Smeyne, J R Mann, S Zackson, J I Morgan.   

Abstract

A genomic clone encoding the Purkinje cell-specific L7 protein has been isolated and utilized to drive the expression of beta-galactosidase in mice. Three independent transgenic lines, germ line transformed with an L7-beta-galactosidase fusion gene, exhibit beta-galactosidase expression in both cerebellar Purkinje cells and retinal bipolar neurons. This distribution is the same as that previously determined for the L7 protein by immunohistochemistry. The transgenic murine lines can be used to obtain populations of marked Purkinje and bipolar neurons. Similar L7 promoter constructs can be used to express other foreign genes specifically in these two classes of neurons.

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Year:  1990        PMID： 2109351     DOI： 10.1126/science.2109351

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  92 in total

1.  Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system.

Authors:  K Tomita; K Moriyoshi; S Nakanishi; F Guillemot; R Kageyama
Journal:  EMBO J       Date:  2000-10-16       Impact factor: 11.598

2.  Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia.

Authors:  Eckhard Flechsig; Ivan Hegyi; Rainer Leimeroth; Armando Zuniga; Daniela Rossi; Antonio Cozzio; Petra Schwarz; Thomas Rülicke; Jürgen Götz; Adriano Aguzzi; Charles Weissmann
Journal:  EMBO J       Date:  2003-06-16       Impact factor: 11.598

Review 3.  Genetic targeting of cerebellar Purkinje cells: history, current status and novel strategies.

Authors:  Jaroslaw J Barski; Matthias Lauth; Michael Meyer
Journal:  Cerebellum       Date:  2002-04       Impact factor: 3.847

4.  Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination.

Authors:  Ryoichi Ichikawa; Kouichi Hashimoto; Taisuke Miyazaki; Motokazu Uchigashima; Miwako Yamasaki; Atsu Aiba; Masanobu Kano; Masahiko Watanabe
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-08       Impact factor: 11.205

5.  High transgene expression by lentiviral vectors causes maldevelopment of Purkinje cells in vivo.

Authors:  Yusuke Sawada; Go Kajiwara; Akira Iizuka; Kiyohiko Takayama; Anton N Shuvaev; Chiho Koyama; Hirokazu Hirai
Journal:  Cerebellum       Date:  2010-09       Impact factor: 3.847

6.  hsp72, a host determinant of measles virus neurovirulence.

Authors:  Thomas Carsillo; Zachary Traylor; Changsun Choi; Stefan Niewiesk; Michael Oglesbee
Journal:  J Virol       Date:  2006-09-13       Impact factor: 5.103

7.  Targeted overexpression of the neurite growth-associated protein B-50/GAP-43 in cerebellar Purkinje cells induces sprouting after axotomy but not axon regeneration into growth-permissive transplants.

Authors:  A Buffo; A J Holtmaat; T Savio; J S Verbeek; J Oberdick; A B Oestreicher; W H Gispen; J Verhaagen; F Rossi; P Strata
Journal:  J Neurosci       Date:  1997-11-15       Impact factor: 6.167

8.  Compartmentation in mammalian cerebellum: Zebrin II and P-path antibodies define three classes of sagittally organized bands of Purkinje cells.

Authors:  N Leclerc; G A Schwarting; K Herrup; R Hawkes; M Yamamoto
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

9.  The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function.

Authors:  Yoshiaki Ohtani; Mariko Miyata; Kouichi Hashimoto; Toshihide Tabata; Yasushi Kishimoto; Masahiro Fukaya; Daisuke Kase; Hidetoshi Kassai; Kazuki Nakao; Tatsumi Hirata; Masahiko Watanabe; Masanobu Kano; Atsu Aiba
Journal:  J Neurosci       Date:  2014-02-12       Impact factor: 6.167

10.  Regulation of proto-oncogene expression in adult and developing lungs.

Authors:  R Molinar-Rode; R J Smeyne; T Curran; J I Morgan
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272
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