Literature DB >> 2109276

D-serine antagonized phencyclidine- and MK-801-induced stereotyped behavior and ataxia.

P C Contreras1.   

Abstract

D-Serine, a selective agonist at the strychnine-insensitive glycine binding site, antagonized PCP-induction of stereotyped behavior and ataxia in a dose-dependent manner. At intraventricular doses of 0.1, 0.5 and 1 mumol/rat, D-serine significantly attenuated PCP-induction of stereotyped behavior in rats. Only doses of 0.5 and 1.0 mumol/rat of D-serine antagonized PCP-induction of ataxia. D-Serine (0.5 mumol/rat) also antagonized MK-801 induced stereotyped behavior and ataxia. These results suggest that agonists at the strychnine-insensitive glycine site may be clinically useful as a novel class of atypical antipsychotic agents.

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Year:  1990        PMID： 2109276     DOI： 10.1016/0028-3908(90)90015-j

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  14 in total

1.  D-Serine facilitates the effectiveness of extinction to reduce drug-primed reinstatement of cocaine-induced conditioned place preference.

Authors:  Sherri Hammond; Claire M Seymour; Ashley Burger; John J Wagner
Journal:  Neuropharmacology       Date:  2012-06-20       Impact factor: 5.250

Review 2.  Modulation of NMDA receptors in the cerebellum. II. Signaling pathways and physiological modulators regulating NMDA receptor function.

Authors:  Ana Sanchez-Perez; Marta Llansola; Omar Cauli; Vicente Felipo
Journal:  Cerebellum       Date:  2005       Impact factor: 3.847

3.  A rapid method for evaluating the behavioral effects of phencyclidine-like dissociative anesthetics in mice.

Authors:  G E Evoniuk; R P Hertzman; P Skolnick
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

4.  Glycine transporter inhibitor attenuates the psychotomimetic effects of ketamine in healthy males: preliminary evidence.

Authors:  Deepak Cyril D'Souza; Nagendra Singh; Jacqueline Elander; Michelle Carbuto; Brian Pittman; Joanna Udo de Haes; Magnus Sjogren; Pierre Peeters; Mohini Ranganathan; Jacques Schipper
Journal:  Neuropsychopharmacology       Date:  2011-11-23       Impact factor: 7.853

5.  Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.

Authors:  Jung Hoon Yang; Akira Wada; Kazuyuki Yoshida; Yurika Miyoshi; Tomoko Sayano; Kayoko Esaki; Masami O Kinoshita; Shozo Tomonaga; Norihiro Azuma; Masahiko Watanabe; Kenji Hamase; Kiyoshi Zaitsu; Takeo Machida; Albee Messing; Shigeyoshi Itohara; Yoshio Hirabayashi; Shigeki Furuya
Journal:  J Biol Chem       Date:  2010-10-21       Impact factor: 5.157

Review 6.  Thinking glutamatergically: changing concepts of schizophrenia based upon changing neurochemical models.

Authors:  Joshua T Kantrowitz; Daniel C Javitt
Journal:  Clin Schizophr Relat Psychoses       Date:  2010-10

7.  The NMDA positive modulator D-cycloserine potentiates the neuroleptic activity of D1 and D2 dopamine receptor blockers in the rat.

Authors:  R Dall'Olio; O Gandolfi
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

8.  The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents.

Authors:  L J Bristow; P H Hutson; L Thorn; M D Tricklebank
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

9.  The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors.

Authors:  Sean M Smith; Jason M Uslaner; Peter H Hutson
Journal:  Open Med Chem J       Date:  2010-05-27

10.  Allosteric regulation of mouse brain serine racemase.

Authors:  Amos Neidle; David S Dunlop
Journal:  Neurochem Res       Date:  2002-12       Impact factor: 3.996
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