Literature DB >> 2109266

Arachidonic and docosahexanoic acid content of bovine brain myelin: implications for the pathogenesis of multiple sclerosis.

K A Ansari1, D W Shoeman.   

Abstract

Lipids were extracted from bovine brain myelin using a mixture of hexane and isopropanol (3:2). Myelin lipids were resolved, using Sep Pak chromatography, into four fractions: Fraction 1 contained neutral lipids, fraction 2, free fatty acids, fraction 3, ethanolamine phospholipids and fraction 4, choline phospholipids. Doscosahexanoic (DHA) and arachidonic (AA) acids in these fractions were measured by RPHPLC. Fraction 2 was analyzed directly, the other three fractions were subjected to alkaline hydrolysis before analysis for DHA and AA. DHA and AA were not found in fraction 1. Both DHA and AA were found in fractions 2 and 3. Only AA was consistently found in fraction 4. These results were confirmed by GC.

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Year:  1990        PMID： 2109266     DOI： 10.1007/bf00969177

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  22 in total

1.  A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.

Authors:  M A Markwell; S M Haas; L L Bieber; N E Tolbert
Journal:  Anal Biochem       Date:  1978-06-15       Impact factor: 3.365

2.  Myelination in rat brain: method of myelin isolation.

Authors:  W T Norton; S E Poduslo
Journal:  J Neurochem       Date:  1973-10       Impact factor: 5.372

3.  Myelination in rat brain: changes in myelin composition during brain maturation.

Authors:  W T Norton; S E Poduslo
Journal:  J Neurochem       Date:  1973-10       Impact factor: 5.372

4.  Rapid separation of free fatty acids from neutral lipids in brain extracts.

Authors:  K A Ansari; D Shoeman
Journal:  J Chromatogr       Date:  1988-05-20

5.  Effect of reactive oxygen species on myelin membrane proteins.

Authors:  G W Konat; R C Wiggins
Journal:  J Neurochem       Date:  1985-10       Impact factor: 5.372

6.  Gangliosides and glycerophospholipids in multiple sclerosis white matter.

Authors:  Y Kishimoto; N S Radin; W W Tourtellotte; J A Parker; H H Itabashi
Journal:  Arch Neurol       Date:  1967-01

7.  Fatty acid and fatty aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin.

Authors:  J S O'Brien; E L Sampson
Journal:  J Lipid Res       Date:  1965-10       Impact factor: 5.922

8.  Macrophage populations associated with multiple sclerosis plaques.

Authors:  M M Esiri; M C Reading
Journal:  Neuropathol Appl Neurobiol       Date:  1987 Nov-Dec       Impact factor: 8.090

9.  Phospholipids and acyl groups of synaptosomal and myelin membranes isolated from the cerebral cortex of squirrel monkey (Saimiri sciureus).

Authors:  G Y Sun; Y Sun
Journal:  Biochim Biophys Acta       Date:  1972-10-05

10.  The fatty acid and aldehyde composition of the major phospholipids of mouse brain.

Authors:  G Y Sun; L A Horrocks
Journal:  Lipids       Date:  1968-01       Impact factor: 1.880
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  5 in total

1.  Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing.

Authors:  Xiaoguang Yang; Wenwen Sheng; Grace Y Sun; James C-M Lee
Journal:  Neurochem Int       Date:  2010-12-22       Impact factor: 3.921

Review 2.  Severe Convulsions and Dysmyelination in Both Jimpy and Cx32/47 -/- Mice may Associate Astrocytic L-Channel Function with Myelination and Oligodendrocytic Connexins with Internodal Kv Channels.

Authors:  Y H Gerald Chaban; Ye Chen; Elna Hertz; Leif Hertz
Journal:  Neurochem Res       Date:  2017-02-18       Impact factor: 3.996

3.  Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms.

Authors:  Marcus O W Grimm; Johanna Kuchenbecker; Sven Grösgen; Verena K Burg; Benjamin Hundsdörfer; Tatjana L Rothhaar; Petra Friess; Martijn C de Wilde; Laus M Broersen; Botond Penke; Mária Péter; László Vígh; Heike S Grimm; Tobias Hartmann
Journal:  J Biol Chem       Date:  2011-02-15       Impact factor: 5.157

Review 4.  Omega-3 fatty acids and cognitive function in women.

Authors:  Jennifer G Robinson; Nkechinyere Ijioma; William Harris
Journal:  Womens Health (Lond)       Date:  2010-01

5.  Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer's Disease.

Authors:  Marcus O W Grimm; Viola J Haupenthal; Tatjana L Rothhaar; Valerie C Zimmer; Sven Grösgen; Benjamin Hundsdörfer; Johannes Lehmann; Heike S Grimm; Tobias Hartmann
Journal:  Int J Mol Sci       Date:  2013-03-13       Impact factor: 5.923
  5 in total

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