Literature DB >> 21092387

Hippocampal atrophy relates to fluid intelligence decline in the elderly.

Aaron Reuben1, Adam M Brickman, Jordan Muraskin, Jason Steffener, Yaakov Stern.   

Abstract

Measures of brain and hippocampal volume in 40 healthy young (aged 18-30 years) and 36 healthy elderly (aged 60-83 years) subjects were compared with composite cognitive function scores in three conceptual domains: memory ability, processing speed, and general fluid intelligence. Through a series of general linear models testing the relationship between these brain measures and cognitive performance scores, a significant positive relationship between hippocampal volume and fluid intelligence ability was found in elderly subjects but not in young. No relationship between the other cognitive domains and brain or hippocampal volume was found. The findings suggest a role of hippocampal atrophy in the decline in fluid intelligence in the elderly.

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Year:  2010        PMID: 21092387      PMCID: PMC3785543          DOI: 10.1017/S135561771000127X

Source DB:  PubMed          Journal:  J Int Neuropsychol Soc        ISSN: 1355-6177            Impact factor:   2.892


  25 in total

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  15 in total

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