Changqing Gao1, Weihua Ye, Libin Li. 1. Department of Cardiovascular Surgery, PLA General Hospital, 28 Fuxing Road, Beijing 100853, PR China. gaochq301@yahoo.com
Abstract
BACKGROUND: To explore the pathological changes of three-dimension structure of ventricular myocardial fibers after anterior myocardial infarction in dog heart. METHODS: Fourteen acute anterior myocardial infarction models were made from healthy dogs (mean weight 17.6 ± 2.5 kg). Six out of 14 dogs with old myocardial infarction were sacrificed, and their hearts were harvested after they survived the acute anterior myocardial infarction for 3 months. Each heart was dissected into ventricular myocardial band (VMB), morphological characters in infarction region were observed, and infarct size percents in descending segment and ascending segment were calculated. RESULTS: Six dog hearts were successfully dissected into VMB. Uncorresponding damages in myocardial fibers of descending segment and ascending segment were found in apical circle in anterior wall infarction. Infarct size percent in the ascending segment was significantly larger than that in the descending segment (23.36 ± 3.15 (SD) vs 30.69 ± 2.40%, P = 0.0033); the long axis of infarction area was perpendicular to the orientation of myocardial fibers in ascending segment; however, the long axis of the infarction area was parallel with the orientation of myocardial fibers in descending segment. CONCLUSIONS: We found that damages were different in both morphology and size in ascending segment and descending segment in heart with myocardial infarction. This may provide an important insight for us to understand the mechanism of heart failure following coronary artery diseases.
BACKGROUND: To explore the pathological changes of three-dimension structure of ventricular myocardial fibers after anterior myocardial infarction in dog heart. METHODS: Fourteen acute anterior myocardial infarction models were made from healthy dogs (mean weight 17.6 ± 2.5 kg). Six out of 14 dogs with old myocardial infarction were sacrificed, and their hearts were harvested after they survived the acute anterior myocardial infarction for 3 months. Each heart was dissected into ventricular myocardial band (VMB), morphological characters in infarction region were observed, and infarct size percents in descending segment and ascending segment were calculated. RESULTS: Six dog hearts were successfully dissected into VMB. Uncorresponding damages in myocardial fibers of descending segment and ascending segment were found in apical circle in anterior wall infarction. Infarct size percent in the ascending segment was significantly larger than that in the descending segment (23.36 ± 3.15 (SD) vs 30.69 ± 2.40%, P = 0.0033); the long axis of infarction area was perpendicular to the orientation of myocardial fibers in ascending segment; however, the long axis of the infarction area was parallel with the orientation of myocardial fibers in descending segment. CONCLUSIONS: We found that damages were different in both morphology and size in ascending segment and descending segment in heart with myocardial infarction. This may provide an important insight for us to understand the mechanism of heart failure following coronary artery diseases.
Authors: F Torrent-Guasp; M Ballester; G D Buckberg; F Carreras; A Flotats; I Carrió; A Ferreira; L E Samuels; J Narula Journal: J Thorac Cardiovasc Surg Date: 2001-08 Impact factor: 5.209
Authors: C A Beltrami; N Finato; M Rocco; G A Feruglio; C Puricelli; E Cigola; F Quaini; E H Sonnenblick; G Olivetti; P Anversa Journal: Circulation Date: 1994-01 Impact factor: 29.690
Authors: Pier L Temporelli; Pantaleo Giannuzzi; Gian L Nicolosi; Roberto Latini; Maria G Franzosi; Francesco Gentile; Luigi Tavazzi; Aldo P Maggioni Journal: J Am Coll Cardiol Date: 2004-05-05 Impact factor: 24.094