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Literature DB >> 21091943

Dietary fatty acids and the aging brain.

Greg M Cole¹, Qiu-Lan Ma, Sally A Frautschy.

Abstract

Aging contributes to physiological decline and vulnerability to disease. In the brain, even with minimal neuronal loss, aging increases oxidative damage, inflammation, demyelination, impaired processing, and metabolic deficits, particularly during pathological brain aging. In this review, the possible role of docosahexaenoic acid (DHA) in the prevention of age-related disruption of brain function is discussed. High-fat diabetogenic diets, cholesterol, and the omega-6 fatty acid arachidonate and its prostaglandin metabolites have all been implicated in promoting the pathogenesis of Alzheimer's disease. Evidence presented here shows DHA acts to oppose this, exerting a plethora of pleiotropic activities to protect against the pathogenesis of Alzheimer's disease.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 21091943 PMCID： PMC4019000 DOI： 10.1111/j.1753-4887.2010.00345.x

Source DB: PubMed Journal: Nutr Rev ISSN： 0029-6643 Impact factor: 7.110

71 in total

1. Diabetes mellitus and the risk of dementia: The Rotterdam Study.

Authors: A Ott; R P Stolk; F van Harskamp; H A Pols; A Hofman; M M Breteler
Journal: Neurology Date: 1999-12-10 Impact factor: 9.910

Review 2. Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model.

Authors: Greg M Cole; Sally A Frautschy
Journal: Nutr Health Date: 2006

Review 3. The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease.

Authors: Greg M Cole; Sally A Frautschy
Journal: Exp Gerontol Date: 2006-10-17 Impact factor: 4.032

Review 4. Fish intake, contaminants, and human health: evaluating the risks and the benefits.

Authors: Dariush Mozaffarian; Eric B Rimm
Journal: JAMA Date: 2006-10-18 Impact factor: 56.272

Review 5. Dietary (n-3) fatty acids and brain development.

Authors: Sheila M Innis
Journal: J Nutr Date: 2007-04 Impact factor: 4.798

6. Brain ferritin iron may influence age- and gender-related risks of neurodegeneration.

Authors: George Bartzokis; Todd A Tishler; Po H Lu; Pablo Villablanca; Lori L Altshuler; Michele Carter; Danny Huang; Nancy Edwards; Jim Mintz
Journal: Neurobiol Aging Date: 2006-03-24 Impact factor: 4.673

7. Docosahexaenoic acid (DHA) improves the age-related impairment of the coupling mechanism between neuronal activation and functional cerebral blood flow response: a PET study in conscious monkeys.

Authors: H Tsukada; T Kakiuchi; D Fukumoto; S Nishiyama; K Koga
Journal: Brain Res Date: 2000-04-17 Impact factor: 3.252

8. n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism.

Authors: J S Rao; R N Ertley; H-J Lee; J C DeMar; J T Arnold; S I Rapoport; R P Bazinet
Journal: Mol Psychiatry Date: 2006-09-19 Impact factor: 15.992

9. Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain.

Authors: C Ramassamy; D Averill; U Beffert; L Theroux; S Lussier-Cacan; J S Cohn; Y Christen; A Schoofs; J Davignon; J Poirier
Journal: Neurobiol Dis Date: 2000-02 Impact factor: 5.996

10. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.

Authors: Kim N Green; Hilda Martinez-Coria; Hasan Khashwji; Eileen B Hall; Karin A Yurko-Mauro; Lorie Ellis; Frank M LaFerla
Journal: J Neurosci Date: 2007-04-18 Impact factor: 6.167

24 in total

1. Omega-3 polyunsaturated fatty acid supplementation improves neurologic recovery and attenuates white matter injury after experimental traumatic brain injury.

Authors: Hongjian Pu; Yanling Guo; Wenting Zhang; Lanting Huang; Guohua Wang; Anthony K Liou; Jia Zhang; Pengyue Zhang; Rehana K Leak; Yun Wang; Jun Chen; Yanqin Gao
Journal: J Cereb Blood Flow Metab Date: 2013-06-26 Impact factor: 6.200

2. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.

Authors: Qiu-Lan Ma; Xiaohong Zuo; Fusheng Yang; Oliver J Ubeda; Dana J Gant; Mher Alaverdyan; Nicolae C Kiosea; Sean Nazari; Ping Ping Chen; Fatiha Nothias; Piu Chan; Edmond Teng; Sally A Frautschy; Greg M Cole
Journal: J Neurosci Date: 2014-05-21 Impact factor: 6.167

Review 3. Primate aging in the mammalian scheme: the puzzle of extreme variation in brain aging.

Authors: Caleb E Finch; Steven N Austad
Journal: Age (Dordr) Date: 2012-01-05

Review 4. Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease.

Authors: Subbiah Pugazhenthi; Limei Qin; P Hemachandra Reddy
Journal: Biochim Biophys Acta Mol Basis Dis Date: 2016-05-06 Impact factor: 5.187

Review 5. The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival.

Authors: N G Bazan
Journal: Prostaglandins Leukot Essent Fatty Acids Date: 2012-09-28 Impact factor: 4.006

Review 6. Neuroprotectin D1 induces neuronal survival and downregulation of amyloidogenic processing in Alzheimer's disease cellular models.

Authors: David T Stark; Nicolas G Bazan
Journal: Mol Neurobiol Date: 2011-03-10 Impact factor: 5.590

7. Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease.

Authors: P A Dacks; D W Shineman; H M Fillit
Journal: J Nutr Health Aging Date: 2013-03 Impact factor: 4.075