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Literature DB >> 21090647

Building addressable libraries: the use of "safety-catch" linkers on microelectrode arrays.

Abstract

A "safety-catch" linker strategy has been used to site-selectively cleave and characterize molecules from a microelectrode array. The linkers are attached to the array by means of an ester and contain either a protected amine or protected alcohol nucleophile that can be released using acid generated at the microelectrodes.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2010 PMID： 21090647 PMCID： PMC3950313 DOI： 10.1021/ja109253t

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

15 in total

1. Building addressable libraries: the use of electrochemistry for generating reactive Pd(II) reagents at preselected sites on a chip.

Authors: Eden Tesfu; Karl Maurer; Steven R Ragsdale; Kevin D Moeller
Journal: J Am Chem Soc Date: 2004-05-26 Impact factor: 15.419

Review 2. The application of cathodic reductions and anodic oxidations in the synthesis of complex molecules.

Authors: Jeffrey B Sperry; Dennis L Wright
Journal: Chem Soc Rev Date: 2006-03-06 Impact factor: 54.564

3. Building addressable libraries: The use of a mass spectrometry cleavable linker for monitoring reactions on a microelectrode array.

Authors: Ceng Chen; Gabriella Nagy; Amy V Walker; Karl Maurer; Andy McShea; Kevin D Moeller
Journal: J Am Chem Soc Date: 2006-12-20 Impact factor: 15.419

4. Building addressable libraries: spatially isolated, chip-based reductive amination reactions.

Authors: Eden Tesfu; Karl Maurer; Kevin D Moeller
Journal: J Am Chem Soc Date: 2006-01-11 Impact factor: 15.419

5. Building addressable libraries: site-selective Lewis acid (scandium(III)) catalyzed reactions.

Authors: Bo Bi; Karl Maurer; Kevin D Moeller
Journal: Angew Chem Int Ed Engl Date: 2009 Impact factor: 15.336

6. Automated electrochemical analysis with combinatorial electrode arrays.

Authors: M G Sullivan; H Utomo; P J Fagan; M D Ward
Journal: Anal Chem Date: 1999-10-01 Impact factor: 6.986

7. Building addressable libraries: the use of electrochemistry for spatially isolating a heck reaction on a chip.

Authors: Jun Tian; Karl Maurer; Eden Tesfu; Kevin D Moeller
Journal: J Am Chem Soc Date: 2005-02-09 Impact factor: 15.419

8. A new porous reaction layer for developing addressable molecular libraries.

Authors: Libo Hu; Jennifer L Bartels; Jeremy W Bartels; Karl Maurer; Kevin D Moeller
Journal: J Am Chem Soc Date: 2009-11-25 Impact factor: 15.419

9. Building addressable libraries: site selective coumarin synthesis and the "real-time" signaling of antibody-coumarin binding.

Authors: Eden Tesfu; Kris Roth; Karl Maurer; Kevin D Moeller
Journal: Org Lett Date: 2006-02-16 Impact factor: 6.005

10. Moving known libraries to an addressable array: a site-selective hetero-Michael reaction.

Authors: Melissae Stuart; Karl Maurer; Kevin D Moeller
Journal: Bioconjug Chem Date: 2008-07-25 Impact factor: 4.774

2 in total

1. Site-selective, cleavable linkers: quality control and the characterization of small molecules on microelectrode arrays.

Authors: Bo Bi; Richard Y-C Huang; Karl Maurer; Ceng Chen; Kevin D Moeller
Journal: J Org Chem Date: 2011-10-10 Impact factor: 4.354

2. Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker.

Authors: Nai-Hua Yeh; Ruby Krueger; Kevin D Moeller
Journal: Org Lett Date: 2021-06-29 Impact factor: 6.072

2 in total