| Literature DB >> 21090242 |
P V Spirin, F Baskaran, N N Orlova, A V Rulina, N A Nikitenko, E L Chernolovskaia, M A Zenkova, V V Vlasov, P M Rubtsov, P M Chumakov, C Stocking, V S Prasolov.
Abstract
In the present study we have applied the siRNA approach for substantial reduction of AML1-ETO and RUNX1 (K83N) expression, which are frequently found in the leukemic cells. We have designed small hairpin RNAs (shRNA) for targeting AML1-ETO oncogene and a region close to the 5'-untranslated region of mRNA for the mutant RUNX1 (K83N) oncogene and expressed the shRNAs in lentiviral vectors. We report a stable reduction in expression of the oncogenes following the introduction of shRNAs into cells.Entities:
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Year: 2010 PMID： 21090242
Source DB: PubMed Journal: Mol Biol (Mosk) ISSN： 0026-8984